Straub, Rainer H. and Cutolo, Maurizio and Pacifici, Roberto (2015) Evolutionary medicine and bone loss in chronic inflammatory diseases-A theory of inflammation-related osteopenia. SEMINARS IN ARTHRITIS AND RHEUMATISM, 45 (2). pp. 220-228. ISSN 0049-0172, 1532-866X
Full text not available from this repository. (Request a copy)Abstract
Objective: Bone loss is typical in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, pemphigus vulgaris, and others. It is also typical in transplantation-related inflammation and during the process of aging. While we recognized that bone loss is tightly linked to immune system activation or inflamm-aging in the form of acute, chronic active, or chronic smoldering inflammation, bone loss is typically discussed to be an "accident of inflammation." Methods: Extensive literature search in PubMed central. Results: Using elements of evolutionary medicine, energy regulation, and neuroendocrine regulation of homeostasis and immune function, we work out that bone waste is an adaptive, evolutionarily positively selected program that is absolutely necessary during acute inflammation. However, when acute inflammation enters a chronic state due to the inability to terminate inflammation (e.g., in autoimmunity or in continuous immunity against microbes), the acute program of bone loss is a misguided adaptive program. Conclusions: The article highlights the complexity of interwoven pathways of osteopenia. (C) 2015 The Authors. Published by Elsevier HS Journals, Inc. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/byqic-nd/4.0/).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | JUVENILE RHEUMATOID-ARTHRITIS; SERUM PARATHYROID-HORMONE; CRITICALLY-ILL PATIENTS; INTENSIVE-CARE-UNIT; VITAMIN-D; NUTRITIONAL-STATUS; MULTIPLE-SCLEROSIS; ENERGY-EXPENDITURE; IMMUNE-SYSTEM; HOST-DEFENSE; bone loss; chronic inflammation; evolutionary medicine; osteopenia; osteoporosis; calcium physiology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Aug 2020 10:56 |
| Last Modified: | 25 Aug 2020 10:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4771 |
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