Zellmer, Stephan and Hanses, Frank and Muzalyova, Anna and Classen, Johanna and Braun, Georg and Piepel, Christiane and Erber, Johanna and Pilgram, Lisa and Walter, Lorenz and Goepel, Siri and Wille, Kai and Hower, Martin and Ruethrich, Maria Madeleine and Rupp, Jan and Degenhardt, Christian and Voigt, Ingo and Borgmann, Stefan and Stecher, Melanie and Jakob, Carolin and Dhillon, Christine and Messmann, Helmut and Ebigbo, Alanna and Roemmele, Christoph (2021) Gastrointestinal bleeding and endoscopic findings in critically and non-critically ill patients with corona virus disease 2019 (COVID-19): Results from Lean European Open Survey on SARS-CoV-2 (LEOSS) and COKA registries. UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 9 (9). pp. 1081-1090. ISSN 2050-6406, 2050-6414
Full text not available from this repository. (Request a copy)Abstract
Background Corona virus disease 2019 (COVID-19) patients are at increased risk for thromboembolic events. It is unclear whether the risk for gastrointestinal (GI) bleeding is also increased. Methods We considered 4128 COVID-19 patients enrolled in the Lean European Open Survey on SARS-CoV-2 (LEOSS) registry. The association between occurrence of GI bleeding and comorbidities as well as medication were examined. In addition, 1216 patients from COKA registry were analyzed focusing on endoscopy diagnostic findings. Results A cumulative number of 97 patients (1.8%) with GI bleeding were identified in the LEOSS registry and COKA registry. Of 4128 patients from the LEOSS registry, 66 patients (1.6%) had a GI bleeding. The rate of GI bleeding in patients with intensive care unit (ICU) admission was 4.5%. The use of therapeutic dose of anticoagulants showed a significant association with the increased incidence of bleeding in the critical phase of disease. The Charlson comorbidity index and the COVID-19 severity index were significantly higher in the group of patients with GI bleeding than in the group of patients without GI bleeding (5.83 (SD = 2.93) vs. 3.66 (SD = 3.06), p < 0.01 and 3.26 (SD = 1.69) vs. 2.33 (SD = 1.53), p < 0.01, respectively). In the COKA registry 31 patients (2.5%) developed a GI bleeding. Of these, the source of bleeding was identified in upper GI tract in 21 patients (67.7%) with ulcer as the most frequent bleeding source (25.8%, n = 8) followed by gastroesophageal reflux (16.1%, n = 5). In three patients (9.7%) GI bleeding source was located in lower GI tract caused mainly by diverticular bleeding (6.5%, n = 2). In seven patients (22.6%) the bleeding localization remained unknown. Conclusion Consistent with previous research, comorbidities and disease severity correlate with the incidence of GI bleeding. Also, therapeutic anticoagulation seems to be associated with a higher risk of GI bleeding. Overall, the risk of GI bleeding seems not to be increased in COVID-19 patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROPHYLAXIS; MANAGEMENT; SOCIETY; COVID-19; critically ill; GI bleeding; LEOSS; SARS-CoV-2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Sep 2022 14:27 |
| Last Modified: | 20 Sep 2022 14:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47727 |
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