Saraav, Iti and Cervantes-Barragan, Luisa and Olias, Philipp and Fu, Yong and Wang, Qiuling and Wang, Leran and Wang, Yi and Mack, Matthias and Baldridge, Megan T. and Stappenbeck, Thaddeus and Colonna, Marco and Sibley, L. David (2021) Chronic Toxoplasma gondii infection enhances to colitis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118 (36): e210673011. ISSN 0027-8424,
Full text not available from this repository. (Request a copy)Abstract
Oral infection with Toxoplasma gondii results in dysbiosis and enteritis, both of which revert to normal during chronic infection. However, whether infection leaves a lasting impact on mucosal responses remains uncertain. Here we examined the effect of the chemical irritant dextran sodium sulfate (DSS) on intestinal damage and wound healing in chronically infected mice. Our findings indicate that prior infection with T. gondii exacerbates damage to the colon caused by DSS and impairs wound healing by suppressing stem cell regeneration of the epithelium. Enhanced tissue damage was attributable to inflammatory monocytes that emerge preactivated from bone marrow, migrate to the intestine, and release inflammatory mediators, including nitric oxide. Tissue damage was reversed by neutralization of inflammatory monocytes or nitric oxide, revealing a causal mechanism for tissue damage. Our findings suggest that chronic infection with T. gondii enhances monocyte activation to increase inflammation associated with a secondary environmental insult.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; NITRIC-OXIDE SYNTHASE; INTERFERON-GAMMA; ORAL INFECTION; INTESTINAL INFLAMMATION; IFN-GAMMA; MONOCYTES; IMMUNITY; CELLS; MICE; monocytes; disbiosis; toxoplasmosis; nitric oxide; inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 06:27 |
| Last Modified: | 21 Sep 2022 06:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47766 |
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