Meintrup, David and Borgmann, Stefan and Seidl, Karlheinz and Stecher, Melanie and Jakob, Carolin E. M. and Pilgram, Lisa and Spinner, Christoph D. and Rieg, Siegbert and Isberner, Nora and Hower, Martin and Vehreschild, Maria and Goepel, Siri and Hanses, Frank and Nowak-Machen, Martina (2021) Specific Risk Factors for Fatal Outcome in Critically Ill COVID-19 Patients: Results from a European Multicenter Study. JOURNAL OF CLINICAL MEDICINE, 10 (17): 3855. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
(1) Background: The aim of our study was to identify specific risk factors for fatal outcome in critically ill COVID-19 patients. (2) Methods: Our data set consisted of 840 patients enclosed in the LEOSS registry. Using lasso regression for variable selection, a multifactorial logistic regression model was fitted to the response variable survival. Specific risk factors and their odds ratios were derived. A nomogram was developed as a graphical representation of the model. (3) Results: 14 variables were identified as independent factors contributing to the risk of death for critically ill COVID-19 patients: age (OR 1.08, CI 1.06-1.10), cardiovascular disease (OR 1.64, CI 1.06-2.55), pulmonary disease (OR 1.87, CI 1.16-3.03), baseline Statin treatment (0.54, CI 0.33-0.87), oxygen saturation (unit = 1%, OR 0.94, CI 0.92-0.96), leukocytes (unit 1000/mu L, OR 1.04, CI 1.01-1.07), lymphocytes (unit 100/mu L, OR 0.96, CI 0.94-0.99), platelets (unit 100,000/mu L, OR 0.70, CI 0.62-0.80), procalcitonin (unit ng/mL, OR 1.11, CI 1.05-1.18), kidney failure (OR 1.68, CI 1.05-2.70), congestive heart failure (OR 2.62, CI 1.11-6.21), severe liver failure (OR 4.93, CI 1.94-12.52), and a quick SOFA score of 3 (OR 1.78, CI 1.14-2.78). The nomogram graphically displays the importance of these 14 factors for mortality. (4) Conclusions: There are risk factors that are specific to the subpopulation of critically ill COVID-19 patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INVASIVE MECHANICAL VENTILATION; CARE-UNIT ADMISSION; HOSPITALIZATION; DEATH; COVID-19; SARS-CoV-2; risk factors; critically ill patients; comorbidities; lasso regression; nomogram |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 07:24 |
| Last Modified: | 21 Sep 2022 07:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47780 |
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