Dirks, Meike and Buchert, Ralph and Wirries, Ann-Katrin and Pflugrad, Henning and Grosse, Gerrit M. and Petrusch, Carlotta and Schutze, Christian and Wilke, Florian and Mamach, Martin and Hamann, Linda and Langer, Laura B. N. and Ding, Xiao-Qi and Barg-Hock, Hannelore and Klempnauer, Jurgen and Wetzel, Christian H. and Lukacevic, Mario and Janssen, Eike and Kessler, Mariella and Bengel, Frank M. and Geworski, Lilli and Rupprecht, Rainer and Ross, Tobias L. and Berding, Georg and Weissenborn, Karin (2021) Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 49 (1). pp. 234-245. ISSN 1619-7070, 1619-7089
Full text not available from this repository. (Request a copy)Abstract
Purpose Calcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) imaging with the translocator protein (TSPO) ligand F-18-GE-180 to evaluate microglial activation in liver-transplanted patients under different regimens of immunosuppression. Methods PET was performed in 22 liver-transplanted patients (3 CNI free, 9 with low-dose CNI, 10 with standard-dose CNI immunosuppression) and 9 healthy controls. The total distribution volume (V-T) estimated in 12 volumes-of-interest was analyzed regarding TSPO genotype, CNI therapy, and cognitive performance. Results In controls, V-T was about 80% higher in high affinity binders (n = 5) compared to mixed affinity binders (n = 3). Mean V-T corrected for TSPO genotype was significantly lower in patients compared to controls, especially in patients in whom CNI dose had been reduced because of nephrotoxic side effect. Conclusion Our results provide evidence of chronic suppression of microglial activity in liver-transplanted patients under CNI therapy especially in patients with high sensitivity to CNI toxicity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; ACTIVATION; PET; TSPO; COMPLICATIONS; MARKER; MODEL; Cognitive function; F-18-GE-180; Imaging; Immunosuppression; Translocator protein (TSPO) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 08:00 |
| Last Modified: | 21 Sep 2022 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47783 |
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