Richter, Julia and John, Katharina and Staiger, Annette M. and Rosenwald, Andreas and Kurz, Katrin and Michgehl, Ulf and Ott, German and Franzenburg, Soren and Kohler, Christian and Finger, Jasmin and Oschlies, Ilske and Paul, Ulrike and Siebert, Reiner and Spang, Rainer and Burkhardt, Birgit and Klapper, Wolfram (2022) Epstein-Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features. BRITISH JOURNAL OF HAEMATOLOGY, 196 (3). pp. 681-689. ISSN 0007-1048, 1365-2141
Full text not available from this repository. (Request a copy)Abstract
Sporadic Burkitt lymphoma (BL) is the most frequent tumour of children and adolescents but a rare subtype of lymphomas in adults. To date most molecular data have been obtained from lymphomas arising in the young. Recently, Epstein-Barr virus (EBV) positive and negative BL in young patients was shown to differ in molecular features. In the present study, we present a large age-overarching cohort of sporadic BL (n = 162) analysed by immunohistochemistry, translocations of MYC proto-oncogene, basic helix-loop-helix transcription factor (MYC), B-cell leukaemia/lymphoma 2 (BCL2) and B-cell leukaemia/lymphoma 6 (BCL6) and by targeted sequencing. We illustrate an age-associated inter-tumoral molecular heterogeneity in this disease. Mutations affecting inhibitor of DNA binding 3, HLH protein (ID3), transcription factor 3 (TCF3) and cyclin D3 (CCND3), which are highly recurrent in paediatric BL, and expression of sex determining region Y-box transcription factor 11 (SOX11) declined with patient age at diagnosis (P = 0 center dot 0204 and P = 0 center dot 0197 respectively). In contrast, EBV was more frequently detected in adult patients (P = 0 center dot 0262). Irrespective of age, EBV-positive sporadic BL showed significantly less frequent mutations in ID3/TCF3/CCND3 (P = 0 center dot 0088) but more often mutations of G protein subunit alpha 13 (GNA13; P = 0 center dot 0368) and forkhead box O1 (FOXO1; P = 0 center dot 0044) compared to EBV-negative tumours. Our findings suggest that among sporadic BL an EBV-positive subgroup of lymphomas increases with patient age that shows distinct pathogenic features reminiscent of EBV-positive endemic BL.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | B-CELL LYMPHOMA; GENE-EXPRESSION; MOLECULAR CHARACTERISTICS; FOLLICULAR LYMPHOMA; CLASSIFICATION; DIAGNOSIS; CHILDREN; FREQUENT; SUBTYPE; GENOME; Epstein-Barr virus status; Burkitt lymphoma; age; mutations |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) Informatics and Data Science > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 08:02 |
| Last Modified: | 21 Sep 2022 08:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47785 |
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