Del Carpio, Edgar and Serrano, Maria L. and Hernandez, Lino and Madden, Waleska and Lubes, Vito and Landaeta, Vanessa R. and Rodriguez-Lugo, Rafael E. and Lubes, Giuseppe and Stern, Anita and Ciangherotti, Carlos and Jimenez, Lissette (2022) Speciation study and biological activity of copper (II) complexes with picolinic and 6-methylpicolinic acid with different components of blood serum of low molecular mass in KNO3 1.0 mol.L-1 at 25 C-degrees. POLYHEDRON, 211: 115562. ISSN 0277-5387, 1873-3719
Full text not available from this repository.Abstract
In the present work, the chemical speciation of ternary complexes of copper (II) with picolinic acid and 6-methylpicolinic acid and different ligands, such as, components of the blood plasma of low molecular mass (lactic acid, oxalic acid, citric acid, and phosphoric acid) were studied by measurements of emf(H) in KNO3 1.00 molL- 1. Potentiometric studies showed a predilection towards the formation of ternary species in solution, except for the copper (II)-picolinate-phosphate systems. The biological activity of the binary and ternary complexes isolated in situ, against reactive oxygen species was studied showing a concentration-dependent effect due to a possible mechanism of electron transfer. Finally, for the complexes Cu(Pic)2 and for the ligands were studied the ligand-receptor interaction on a PI3k of human origin by molecular docking, showing that, by themselves, the ligands are not capable of interacting with the active site of the enzyme. The metallic center is fundamental to generate reversible electrostatic interactions, that can be key to the indirect hypoglycemic effect exhibited by the Cu(Pic)2 complex reported in the literature.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OXIDATIVE STRESS; REACTIVE OXYGEN; DNA-BINDING; ANTIOXIDANT; CHEMISTRY; CU(II); METAL; SUPPLEMENTATION; ANTIBACTERIAL; BIOCHEMISTRY; Chemical equilibrium; Chemical speciation; Copper; Molecular docking; Oxidative stress; Super oxide radical |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Anorganische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2022 07:02 |
| Last Modified: | 13 Sep 2022 07:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47790 |
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