Keller, Karsten and Schmitt, Volker H. and Vosseler, Markus and Brochhausen, Christoph and Munzel, Thomas and Hobohm, Lukas and Espinola-Klein, Christine (2021) Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease. JOURNAL OF CLINICAL MEDICINE, 10 (21): 5033. ISSN , 2077-0383
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Background: In patients with peripheral artery disease (PAD), the impact of diabetes mellitus (DM) on patient-profile and adverse in-hospital events is not well investigated. Methods: The German nationwide inpatient sample 2005-2019 was used for this analysis. Hospitalized PAD patients were stratified for DM and the influence of DM on patient-profile and adverse in-hospital events was investigated. Results: Our study comprised 2,654,871 hospitalizations (54.3% aged & GE;70 years, 36.7% females) of patients with PAD in Germany 2005-2019. Among these, 864,691 (32.6%) patients had DM and 76,716 (2.9%) died during hospitalization. Diabetic PAD patients revealed an aggravated cardiovascular profile (Charlson Comorbidity Index: 6.0 (5.0-8.0) vs. 4.0 (3.0-5.0), p < 0.001). PAD patients with DM showed a higher rate of in-hospital mortality (3.5% vs. 2.6%, p < 0.001), as well as major adverse cardiovascular and cerebrovascular events (MACCE, 4.7% vs. 3.3%, p < 0.001) and had more often operated with amputation surgery (16.4% vs. 9.1%, p < 0.001). DM was an independent predictor of in-hospital mortality (OR 1.077 (95%CI 1.060-1.093), p < 0.001) and MACCE (OR 1.118 (95%CI 1.103-1.133), p < 0.001). In addition, amputations were also associated with DM (OR 1.804 (95%CI 1.790-1.818)), p < 0.001). Conclusions: DM is associated with an unfavorable clinical patient-profile and higher risk for adverse events in PAD patients, including substantially increased in-hospital mortality as well as MACCE rate, and were more often associated with amputation surgeries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOWER-EXTREMITY AMPUTATION; RISK-FACTORS; INTERMITTENT CLAUDICATION; EPIDEMIOLOGY; PREVALENCE; PEOPLE; TRENDS; GUIDELINES; MANAGEMENT; MEN; diabetes mellitus; peripheral artery disease; myocardial infarction; amputation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 07:15 |
| Last Modified: | 21 Sep 2022 07:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47795 |
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