Kuhn, Christian and Menke, Maja and Senger, Frauke and Mack, Claudia and Dierck, Franziska and Hille, Susanne and Schmidt, Inga and Brunke, Gabriele and Buenger, Pia and Schmiedel, Nesrin and Will, Rainer and Sossalla, Samuel and Frank, Derk and Eschenhagen, Thomas and Carrier, Lucie and Luellmann-Rauch, Renate and Rangrez, Ashraf Yusuf and Frey, Norbert (2021) FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo. JACC-BASIC TO TRANSLATIONAL SCIENCE, 6 (4). pp. 365-380. ISSN 2452-302X,
Full text not available from this repository. (Request a copy)Abstract
Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, Fyco/-deficient mice subjected to starvation or pressure overload are unable to respond with induction of autophagy and develop impaired cardiac function. FYCO1 overexpression leads to induction of autophagy in isolated cardiomyocytes and transgenic mouse hearts, thereby rescuing cardiac dysfunction in response to biomechanical stress. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STARVATION-INDUCED AUTOPHAGY; PROTEIN; MATURATION; RAB7; autophagy; FYCO1; heart failure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 08:11 |
| Last Modified: | 21 Sep 2022 08:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47802 |
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