Marx, Alexander and Belharazem, Djeda and Lee, De-Hyung and Popovic, Zoran V. and Reißfelder, Christoph and Schalke, Berthold and Schölch, Sebastian and Ströbel, Philipp and Weis, Cleo-Aron and Yamada, Yosuke (2021) Molecular pathology of thymomas: implications for diagnosis and therapy. VIRCHOWS ARCHIV, 478 (1). pp. 101-110. ISSN 0945-6317, 1432-2307
Full text not available from this repository. (Request a copy)Abstract
Thymomas exhibit a unique genomic landscape, comprising the lowest on average total mutational burden among adult human cancers; a unique point mutation in the GTF2I gene in WHO type A and AB thymomas (and rarely others); almost unique KMT2A-MAML2 translocations in rare WHO type B2 and B3 thymomas; a unique YAP1-MAML2 translocation in almost all metaplastic thymomas; and unique miRNA profiles in relation to GTF2I mutational status and WHO histotypes. While most thymomas can be diagnosed solely on the basis of morphological features, mutational analyses can solve challenging differential diagnostic problems. No molecular biomarkers have been identified that predict the response of unresectable thymomas to chemotherapy or agents with known molecular targets. Despite the common and strong expression of PDL1 in thymomas, immune checkpoint inhibitors are rarely applicable due to the poor predictability of common, life-threatening autoimmune side effects that are related to the unrivaled propensity of thymomas towards autoimmunity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AIRE; Microsatellite instability; MicroRNA; SMARCA4; Myasthenia gravis; Immune checkpoint inhibitors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Dec 2022 07:59 |
| Last Modified: | 21 Dec 2022 07:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47810 |
Actions (login required)
 |
View Item |
