Struck, Julian P. and Schnoor, Maike and Schulze, Andrea and Hupe, Marie C. and Ozimek, Tomasz and Oppolzer, Immanuel A. and Schnabel, Marco J. and Burger, Maximilian and Darr, Christopher and Gruenwald, Viktor and Hadaschik, Boris and Weinke, Maximilian and Kuebler, Hubert and Klockenbusch, Jonas C. and Grabbert, Markus T. and Gratzke, Christian and Kramer, Mario W. and Katalinic, Alexander and Merseburger, Axel S. (2022) Impact of COVID-19 crisis on medical care of patients with metastasized uro-oncologic disease under systemic cancer therapy: a multicenter study in German university hospitals. WORLD JOURNAL OF UROLOGY, 40 (2). pp. 409-418. ISSN 0724-4983, 1433-8726
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Purpose To date, over 4.2 million Germans and over 235 million people worldwide have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Uro-oncology (UO) patients are particularly vulnerable but in urgent need of life-saving systemic treatments. Our multicentric study examined the impact of the COVID-19 crisis on the medical care of UO patients in German university hospitals receiving ongoing systemic anti-cancer treatment and to detect the delay of medical care, defined as deferred medical treatment or deviation of the pre-defined follow-up assessment. Methods Data of 162 UO patients with metastatic disease undergoing systemic cancer treatment at five university hospitals in Germany were included in our analyses. The focus of interest was any delay or change in treatment between February 2020 and May 2020 (first wave of the COVID-19 crisis in Germany). Statistical analysis of contingency tables were performed using Pearson's chi-squared and Fisher's exact tests, respectively. Effect size was determined using Cramer's V (V). Results Twenty-four of the 162 patients (14.8%) experienced a delay in systemic treatment of more than 2 weeks. Most of these received immuno-oncologic (IO) treatments (13/24, 54.2%, p = 0.746). Blood tests were delayed or canceled significantly more often in IO patients but with a small effect size (21.1%, p = 0.042, V = 0.230). Treatment of patients with renal cell carcinoma (12/73, 16.4%) and urothelial carcinoma (7/32, 21.9%) was affected the most. Conclusions Our data show that the COVID-19 pandemic impacted the medical care of UO patients, but deferment remained modest. There was a tendency towards delays in IO and ADT treatments in particular.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SOCIAL MEDIA; Uro-oncology; COVID19; COVID-19; SARS-CoV-2; Pandemic; Medical care |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 08:24 |
| Last Modified: | 21 Sep 2022 08:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47811 |
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