Herrmann, Marietta and Diederichs, Solvig and Melnik, Svitlana and Riegger, Jana and Trivanovic, Drenka and Li, Shushan and Jenei-Lanzl, Zsuzsa and Brenner, Rolf E. and Huber-Lang, Markus and Zaucke, Frank and Schildberg, Frank A. and Grassel, Susanne (2021) Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 8: 624096. ISSN 2296-4185
Full text not available from this repository. (Request a copy)Abstract
The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained attention in musculoskeletal research. EVs have been associated with various musculoskeletal pathologies as well as suggested as treatment option. EVs play a pivotal role in communication between cells and their environment. Thereby, the EV cargo is highly dependent on their cellular origin. In this review, we summarize putative mechanisms by which EVs can contribute to musculoskeletal tissue homeostasis, regeneration and disease, in particular matrix remodeling and mineralization, pro-angiogenic effects and immunomodulatory activities. Mesenchymal stromal cells (MSCs) present the most frequently used cell source for EV generation for musculoskeletal applications, and herein we discuss how the MSC phenotype can influence the cargo and thus the regenerative potential of EVs. Induced pluripotent stem cell-derived mesenchymal progenitor cells (iMPs) may overcome current limitations of MSCs, and iMP-derived EVs are discussed as an alternative strategy. In the last part of the article, we focus on therapeutic applications of EVs and discuss both practical considerations for EV production and the current state of EV-based therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; CHONDROGENIC PROGENITOR CELLS; DENSITY-GRADIENT SEPARATION; STROMAL CELLS; BONE-MARROW; ENHANCE ANGIOGENESIS; EXOSOME ISOLATION; CELLULAR SENESCENCE; OSTEOGENIC DIFFERENTIATION; INDUCE ANGIOGENESIS; extracellular vesicles; exosomes; musculoskeletal diseases; MSC; iMP; cell-free therapeutics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Dec 2022 13:16 |
| Last Modified: | 16 Dec 2022 13:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47833 |
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