Santo-Angles, Aniol and Salvador, Raymond and Gomar, Jesus J. and Guerrero-Pedraza, Amalia and Ramiro, Nuria and Tristany, Josep and Teixido, Cristina and Ortiz-Gil, Jordi and Aguirre, Candibel and Bosque, Clara and Lopez-Araquistain, Laura and Maristany, Teresa and Salgado-Pineda, Pilar and Sarro, Salvador and McKenna, Peter J. and Bernardo, Miquel and Pomarol-Clotet, Edith and Schwarzbach, Jens (2021) Interindividual variability of functional connectome in schizophrenia. SCHIZOPHRENIA RESEARCH, 235. pp. 65-73. ISSN 0920-9964, 1573-2509
Full text not available from this repository. (Request a copy)Abstract
Schizophrenia is a complex psychiatric disorder that displays an outstanding interindividual variability in clinical manifestation and neurobiological substrates. A better characterization and quantification of this heterogeneity could guide the search for both common abnormalities (linked to lower intersubject variability) and the presence of biological subtypes (leading to a greater heterogeneity across subjects). In the current study, we address interindividual variability in functional connectome by means of resting-state fMRI in a large sample of patients with schizophrenia and healthy controls. Among the different metrics of distance/dissimilarity used to assess variability, geodesic distance showed robust results to head motion. The main findings of the current study point to (i) a higher between subject heterogeneity in the functional connectome of patients, (ii) variable levels of heterogeneity throughout the cortex, with greater variability in frontoparietal and default mode networks, and lower variability in the salience network, and (iii) an association of whole-brain variability with levels of clinical symptom severity and with topological properties of brain networks, suggesting that the average functional connectome overrepresents those patients with lower functional integration and with more severe clinical symptoms. Moreover, after performing a graph theoretical analysis of brain networks, we found that patients with more severe clinical symptoms had decreased connectivity at both whole-brain level and within the salience network, and that patients with higher negative symptoms had large-scale functional integration deficits.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONNECTIVITY; HETEROGENEITY; CLASSIFICATION; ARCHITECTURE; METAANALYSIS; HYPOTHESIS; PSYCHOSIS; NETWORKS; DEFICITS; Resting-state fMRI; Functional connectome; Interindividual variability; Brain heterogeneity; Graph theory; Schizophrenia; Negative symptoms |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 11:12 |
| Last Modified: | 21 Sep 2022 11:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47848 |
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