Proske, Pia and Distelmaier, Laura and Aramayo-Singelmann, Carmen and Koliastas, Nikolaos and Iannaccone, Antonella and Papathanasiou, Maria and Temme, Christian and Klump, Hannes and Lenz, Veronika and Koldehoff, Michael and Carpinteiro, Alexander and Reinhardt, Hans Christian and Koninger, Angela and Roth, Alexander and Yamamoto, Raina and Duhrsen, Ulrich and Alashkar, Ferras (2021) Pregnancies and Neonatal Outcomes in Patients with Sickle Cell Disease (SCD): Still a (High-)Risk Constellation? JOURNAL OF PERSONALIZED MEDICINE, 11 (9): 870. ISSN , 2075-4426
Full text not available from this repository. (Request a copy)Abstract
Background: This monocentric study conducted at the University Hospital of Essen aims to describe maternal and fetal/neonatal outcomes in sickle cell disease (SCD) documented between 1996 to 2021 (N = 53), reflecting the largest monocentric analysis carried out in Germany. Methods/Results: 46 pregnancies in 22 patients were followed. None of the patients died. In total, 35% (11/31) of pregnancies were preterm. 15 pregnancies in eight patients were conceived on hydroxycarbamide (HC), of which nine had a successful outcome and three were terminated prematurely. There was no difference regarding the rate of spontaneous abortions in patients receiving HC compared to HC-naive patients prior to conception. In patients other than HbS/C disease, pregnancies were complicated by vaso-occlusive crises (VOCs)/acute pain crises (APCs) (96%, 23/24); acute chest syndrome (ACS) (13%, 3/24), transfusion demand (79%, 19/24), urinary tract infections (UTIs) (42%, 10/24) and thromboembolic events (8%, 2/24). In HbS/C patients complications included: VOCs/APCs (43%, 3/7; ACS: 14%, 1/7), transfusion demand (14%, 1/7), and UTIs (14%, 1/7). Independent of preterm deliveries, a significant difference with respect to neonatal growth in favor of neonates from HbS/C mothers was observed. Conclusion: Our data support the results of previous studies, highlighting the high rate of maternal and fetal/neonatal complications in pregnant SCD patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROPHYLACTIC TRANSFUSION; WOMEN; MORTALITY; ALLOIMMUNIZATION; HYDROXYUREA; EXPERIENCE; UPDATE; pregnancy; sickle cell disease; vaso-occlusive (VOC); transfusion; complications; genotype-phenotype correlation and patient stratification; patient registries and standardization |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Sep 2022 06:33 |
| Last Modified: | 23 Sep 2022 06:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47915 |
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