Spiljar, Martina and Steinbach, Karin and Rigo, Dorothee and Suarez-Zamorano, Nicolas and Wagner, Ingrid and Hadadi, Noushin and Vincenti, Ilena and Page, Nicolas and Klimek, Bogna and Rochat, Mary-Aude and Kreutzfeldt, Mario and Chevalier, Claire and Stojanovic, Ozren and Bejuy, Olivia and Colin, Didier and Mack, Matthias and Cansever, Dilay and Greter, Melanie and Merkler, Doron and Trajkovski, Mirko (2021) Cold exposure protects from neuroinflammation through immunologic reprogramming. CELL METABOLISM, 33 (11). 2231-+. ISSN 1550-4131, 1932-7420
Full text not available from this repository. (Request a copy)Abstract
Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immunemediated diseases is unclear. Ly6C(hi) monocytes are key effectors in CNS autoimmunity with an elusive role in priming naive autoreactive T cells. Here, we provide unbiased analysis of the immune changes in various compartments during cold exposure and show that this energetically costly stimulus markedly ameliorates active experimental autoimmune encephalomyelitis (EAE). Cold exposure decreases MHCII on monocytes at steady state and in various inflammatory mouse models and suppresses T cell priming and pathogenicity through the modulation of monocytes. Genetic or antibody-mediated monocyte depletion or adoptive transfer of Th1- or Th17-polarized cells for EAE abolishes the cold-induced effects on T cells or EAE, respectively. These findings provide a mechanistic link between environmental temperature and neuroinflammation and suggest competition between cold-induced metabolic adaptations and autoimmunity as energetic trade-off beneficial for the immune-mediated diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; DENDRITIC CELLS; ADIPOSE-TISSUE; NERVOUS-SYSTEM; MONOCYTES; IMMUNOMETABOLISM; DIFFERENTIATION; HETEROGENEITY; MACROPHAGES; ACTIVATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Sep 2022 08:19 |
| Last Modified: | 26 Sep 2022 08:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47955 |
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