Korb, Judith and Meusemann, Karen and Aumer, Denise and Bernadou, Abel and Elsner, Daniel and Feldmeyer, Barbara and Foitzik, Susanne and Heinze, Juergen and Libbrecht, Romain and Lin, Silu and Majoe, Megha and Kuhn, Jose Manuel Monroy and Nehring, Volker and Negroni, Matteo A. and Paxton, Robert J. and Seguret, Alice C. and Stoldt, Marah and Flatt, Thomas (2021) Comparative transcriptomic analysis of the mechanisms underpinning ageing and fecundity in social insects. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 376 (1823): 20190728. ISSN 0962-8436, 1471-2970
Full text not available from this repository. (Request a copy)Abstract
The exceptional longevity of social insect queens despite their lifelong high fecundity remains poorly understood in ageing biology. To gain insights into the mechanisms that might underlie ageing in social insects, we compared gene expression patterns between young and old castes (both queens and workers) across different lineages of social insects (two termite, two bee and two ant species). After global analyses, we paid particular attention to genes of the insulin/insulin-like growth factor 1 signalling (IIS)/target of rapamycin (TOR)/juvenile hormone (JH) network, which is well known to regulate lifespan and the trade-off between reproduction and somatic maintenance in solitary insects. Our results reveal a major role of the downstream components and target genes of this network (e.g. JH signalling, vitellogenins, major royal jelly proteins and immune genes) in affecting ageing and the caste-specific physiology of social insects, but an apparently lesser role of the upstream IIS/TOR signalling components. Together with a growing appreciation of the importance of such downstream targets, this leads us to propose the TI-J-LiFe (TOR/IIS-JH-Lifespan and Fecundity) network as a conceptual framework for understanding the mechanisms of ageing and fecundity in social insects and beyond. This article is part of the theme issue 'Ageing and sociality: why, when and how does sociality change ageing patterns?'
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | JUVENILE-HORMONE REGULATION; EUSOCIAL ORCHID BEE; SOMATIC MAINTENANCE; TEMNOTHORAX-RUGATULUS; MOLECULAR-MECHANISMS; LOWER TERMITE; LIFE-HISTORY; TRADE-OFF; EVOLUTION; REPRODUCTION; social insects; longevity; insulin; TOR; juvenile hormone; transcriptomics |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Zoologie/Evolutionsbiologie (Prof. Dr. Jürgen Heinze) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2022 08:36 |
| Last Modified: | 13 Sep 2022 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47964 |
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