van Roekel, Eline H. and Bours, Martijn J. L. and van Delden, Linda and Breukink, Stephanie O. and Aquarius, Michel and Keulen, Eric T. P. and Gicquiau, Audrey and Viallon, Vivian and Rinaldi, Sabina and Vineis, Paolo and Arts, Ilja C. W. and Gunter, Marc J. and Leitzmann, Michael F. and Scalbert, Augustin and Weijenberg, Matty P. (2021) Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment. SCIENTIFIC REPORTS, 11 (1): 13738. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n=252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value<0.05) to higher concentrations of arginine, citrulline and histidine, eight lysophosphatidylcholines, nine diacylphosphatidylcholines, 13 acyl-alkylphosphatidylcholines, two sphingomyelins, and acylcarnitine C10:1. No intra-individual associations were found. LPA was not associated with any metabolite. More MVPA was associated with higher concentrations of several lipids and three amino acids, which have been linked to anti-inflammatory processes and improved metabolic health. Mechanistic studies are needed to investigate whether these metabolites may affect prognosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; TARGETED METABOLOMICS; HEALTH; SERUM; REPRODUCIBILITY; CLASSIFICATION; QUESTIONNAIRE; BIOMARKERS; SIGNATURES; MORTALITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Sep 2022 06:15 |
| Last Modified: | 27 Sep 2022 06:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47995 |
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