Salmanton-Garcia, Jon and Sprute, Rosanne and Stemler, Jannik and Bartoletti, Michele and Dupont, Damien and Valerio, Maricela and Garcia-Vidal, Carolina and Falces-Romero, Iker and Machado, Marina and de la Villa, Sofia and Schroeder, Maria and Hoyo, Irma and Hanses, Frank and Ferreira-Paim, Kennio and Giacobbe, Daniele Roberto and Meis, Jacques F. and Gangneux, Jean-Pierre and Rodriguez-Guardado, Azucena and Antinori, Spinello and Sal, Ertan and Malaj, Xhorxha and Seidel, Danila and Cornely, Oliver A. and Koehler, Philipp (2021) COVID-19-Associated Pulmonary Aspergillosis, March-August 2020. EMERGING INFECTIOUS DISEASES, 27 (4). pp. 1077-1086. ISSN 1080-6040, 1080-6059
Full text not available from this repository. (Request a copy)Abstract
Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because of the severe immunomodulation and lymphocyte depletion caused by this virus and the subsequent administration of drugs directed at the immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 patients who had coronavirus disease-associated pulmonary aspergillosis (CAPA) worldwide during March-August 2020. Overall, 182 patients were admitted to the intensive care unit (ICU), including 180 with acute respiratory distress syndrome and 175 who received mechanical ventilation. CAPA was diagnosed a median of 10 days after coronavirus disease diagnosis. Aspergillus fumigatus was identified in 80.3% of patient cultures, 4 of which were azole-resistant. Most (52.7%) patients received voriconazole. In total, 52.2% of patients died; of the deaths, 33.0% were attributed to CAPA. We found that the cumulative incidence of CAPA in the ICU ranged from 1.0% to 39.1%.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INVASIVE ASPERGILLOSIS; CORONAVIRUS DISEASE; COVID-19; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Sep 2022 07:14 |
| Last Modified: | 27 Sep 2022 07:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48009 |
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