Kleineberg, Nina N. and Knauss, Samuel and Guelke, Eileen and Pinnschmidt, Hans O. and Jakob, Carolin E. M. and Lingor, Paul and Hellwig, Kerstin and Berthele, Achim and Hoeglinger, Guenter and Fink, Gereon R. and Endres, Matthias and Gerloff, Christian and Klein, Christine and Stecher, Melanie and Classen, Annika Y. and Rieg, Siegbert and Borgmann, Stefan and Hanses, Frank and Ruethrich, Maria M. and Hower, Martin and Tometten, Lukas and Haselberger, Martina and Piepel, Christiane and Merle, Uta and Dolff, Sebastian and Degenhardt, Christian and Jensen, Bjoern-Erik O. and Vehreschild, Maria J. G. T. and Erber, Johanna and Franke, Christiana and Warnke, Clemens (2021) Neurological symptoms and complications in predominantly hospitalized COVID-19 patients: Results of the European multinational Lean European Open Survey on SARS-Infected Patients (LEOSS). EUROPEAN JOURNAL OF NEUROLOGY, 28 (12). pp. 3925-3937. ISSN 1351-5101, 1468-1331
Full text not available from this repository. (Request a copy)Abstract
Background and purpose During acute coronavirus disease 2019 (COVID-19) infection, neurological signs, symptoms and complications occur. We aimed to assess their clinical relevance by evaluating real-world data from a multinational registry. Methods We analyzed COVID-19 patients from 127 centers, diagnosed between January 2020 and February 2021, and registered in the European multinational LEOSS (Lean European Open Survey on SARS-Infected Patients) registry. The effects of prior neurological diseases and the effect of neurological symptoms on outcome were studied using multivariate logistic regression. Results A total of 6537 COVID-19 patients (97.7% PCR-confirmed) were analyzed, of whom 92.1% were hospitalized and 14.7% died. Commonly, excessive tiredness (28.0%), headache (18.5%), nausea/emesis (16.6%), muscular weakness (17.0%), impaired sense of smell (9.0%) and taste (12.8%), and delirium (6.7%) were reported. In patients with a complicated or critical disease course (53%) the most frequent neurological complications were ischemic stroke (1.0%) and intracerebral bleeding (ICB; 2.2%). ICB peaked in the critical disease phase (5%) and was associated with the administration of anticoagulation and extracorporeal membrane oxygenation (ECMO). Excessive tiredness (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.20-1.68) and prior neurodegenerative diseases (OR 1.32, 95% CI 1.07-1.63) were associated with an increased risk of an unfavorable outcome. Prior cerebrovascular and neuroimmunological diseases were not associated with an unfavorable short-term outcome of COVID-19. Conclusion Our data on mostly hospitalized COVID-19 patients show that excessive tiredness or prior neurodegenerative disease at first presentation increase the risk of an unfavorable short-term outcome. ICB in critical COVID-19 was associated with therapeutic interventions, such as anticoagulation and ECMO, and thus may be an indirect complication of a life-threatening systemic viral infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; COVID-19; neurological manifestations; SARS-CoV-2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Sep 2022 08:24 |
| Last Modified: | 27 Sep 2022 08:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48018 |
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