Garcia, Katherine Yasmin M. and Quimque, Mark Tristan J. and Primahana, Gian and Ratzenboeck, Andreas and Cano, Mark Joseph B. and Llaguno, Jeremiah Francis A. and Dahse, Hans-Martin and Phukhamsakda, Chayanard and Surup, Frank and Stadler, Marc and Macabeo, Allan Patrick G. (2021) COX Inhibitory and Cytotoxic Naphthoketal-Bearing Polyketides from Sparticola junci. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (22): 12379. ISSN 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Axenic fermentation on solid rice of the saprobic fungus Sparticola junci afforded two new highly oxidized naphthalenoid polyketide derivatives, sparticatechol A (1) and sparticolin H (2) along with sparticolin A (3). The structures of 1 and 2 were elucidated on the basis of their NMR and HR-ESIMS spectroscopic data. Assignment of absolute configurations was performed using electronic circular dichroism (ECD) experiments and Time-Dependent Density Functional Theory (TDDFT) calculations. Compounds 1-3 were evaluated for COX inhibitory, antiproliferative, cytotoxic and antimicrobial activities. Compounds 1 and 2 exhibited strong inhibitory activities against COX-1 and COX-2. Molecular docking analysis of 1 conferred favorable binding against COX-2. Sparticolin H (2) and A (3) showed a moderate antiproliferative effect against myelogenous leukemia K-562 cells and weak cytotoxicity against HeLa and mouse fibroblast cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CLADOSPIRONE BISEPOXIDE; FUNGUS; BIOSYNTHESIS; DERIVATIVES; SYSTEM; Sparticola junci; structure elucidation; ECD-TDDFT; COX inhibitory; molecular docking; antiproliferative; cytotoxic |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2022 09:41 |
| Last Modified: | 13 Sep 2022 09:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48024 |
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