Belliato, Mirko and Epis, Francesco and Cremascoli, Luca and Ferrari, Fiorenza and Quattrone, Maria Giovanna and Fisser, Christoph and Malfertheiner, Maximilian Valentin and Taccone, Fabio Silvio and Di Nardo, Matteo and Broman, Lars Mikael and Lorusso, Roberto (2021) Mechanical Power during Veno-Venous Extracorporeal Membrane Oxygenation Initiation: A Pilot-Study. MEMBRANES, 11 (1): 30. ISSN , 2077-0375
Full text not available from this repository. (Request a copy)Abstract
Mechanical power (MP) represents a useful parameter to describe and quantify the forces applied to the lungs during mechanical ventilation (MV). In this multi-center, prospective, observational study, we analyzed MP variations following MV adjustments after veno-venous extra-corporeal membrane oxygenation (VV ECMO) initiation. We also investigated whether the MV parameters (including MP) in the early phases of VV ECMO run may be related to the intensive care unit (ICU) mortality. Thirty-five patients with severe acute respiratory distress syndrome were prospectively enrolled and analyzed. After VV ECMO initiation, we observed a significant decrease in median MP (32.4 vs. 8.2 J/min, p < 0.001), plateau pressure (27 vs. 21 cmH(2)O, p = 0.012), driving pressure (11 vs. 8 cmH(2)O, p = 0.014), respiratory rate (RR, 22 vs. 14 breaths/min, p < 0.001), and tidal volume adjusted to patient ideal body weight (V-T/IBW, 5.5 vs. 4.0 mL/kg, p = 0.001) values. During the early phase of ECMO run, RR (17 vs. 13 breaths/min, p = 0.003) was significantly higher, while positive end-expiratory pressure (10 vs. 14 cmH(2)O, p = 0.048) and V-T/IBW (3.0 vs. 4.0 mL/kg, p = 0.028) were lower in ICU non-survivors, when compared to the survivors. The observed decrease in MP after ECMO initiation did not influence ICU outcome. Waiting for large studies assessing the role of these parameters in VV ECMO patients, RR and MP monitoring should not be underrated during ECMO.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY-DISTRESS-SYNDROME; PHYSIOLOGY SCORE II; OPEN LUNG CONCEPT; DRIVING PRESSURE; TIDAL VOLUME; VENTILATION; FAILURE; PREDICTOR; MORTALITY; SURVIVAL; veno-venous extracorporeal membrane oxygenation; acute respiratory distress syndrome; ventilator-induced lung injury; mechanical ventilation; mechanical power; respiratory rate |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Sep 2022 08:36 |
| Last Modified: | 27 Sep 2022 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48031 |
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