Vettermann, Franziska J. and Harris, Stefanie and Schmitt, Julia and Unterrainer, Marcus and Lindner, Simon and Rauchmann, Boris-Stephan and Palleis, Carla and Weidinger, Endy and Beyer, Leonie and Eckenweber, Florian and Schuster, Sebastian and Biechele, Gloria and Ferschmann, Christian and Milenkovic, Vladimir M. and Wetzel, Christian H. and Rupprecht, Rainer and Janowitz, Daniel and Buerger, Katharina and Perneczky, Robert and Hoeglinger, Guenter U. and Levin, Johannes and Haass, Christian and Tonn, Joerg C. and Niyazi, Maximilian and Bartenstein, Peter and Albert, Nathalie L. and Brendel, Matthias (2021) Impact of TSPO Receptor Polymorphism on [F-18]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders. LIFE-BASEL, 11 (6): 484. ISSN , 2075-1729
Full text not available from this repository. (Request a copy)Abstract
TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical relevance of [F-18]GE-180 is still unclear. We evaluated the impact of rs6971-SNP on in vivo [F-18]GE-180 binding in a healthy brain and in pseudo-reference tissue in neuro-oncological and neurodegenerative diseases. Standardized uptake values (SUVs) of [F-18]GE-180-PET were assessed using a manually drawn region of interest in the frontoparietal and cerebellar hemispheres. The SUVs were compared between the LABs, MABs and HABs in control, glioma, four-repeat tauopathy (4RT) and Alzheimer's disease (AD) subjects. Second, the SUVs were compared between the patients and controls within their rs6971-subgroups. After excluding patients with prior therapy, 24 LABs (7 control, 5 glioma, 6 4RT and 6 AD) were analyzed. Age- and sex-matched MABs (n = 38) and HABs (n = 50) were selected. The LABs had lower frontoparietal and cerebellar SUVs when compared with the MABs and HABs, but no significant difference was observed between the MABs and HABs. Within each rs6971 group, no SUV difference between the patients and controls was detected in the pseudo-reference tissues. The rs6971-SNP affects [F-18]GE-180 quantification, revealing lower binding in the LABs when compared to the MABs and HABs. The frontoparietal and cerebellar ROIs were successfully validated as pseudo-reference regions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN 18 KDA; TRANSLOCATOR PROTEIN; BENZODIAZEPINE-RECEPTOR; MICROGLIAL ACTIVATION; KINETIC-ANALYSIS; PET; RADIOLIGAND; NEUROINFLAMMATION; RADIOTRACER; AFFINITY; microglia; neurodegeneration; Alzheimer's disease; neuro-oncology; 4R-tauopathy; TSPO-PET |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Sep 2022 12:54 |
| Last Modified: | 27 Sep 2022 12:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48085 |
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