Loesslein, Anne Kathrin and Lohrmann, Florens and Scheuermann, Lisa and Gharun, Kourosh and Neuber, Jana and Kolter, Julia and Forde, Aaron James and Kleimeyer, Christian and Poh, Ying Yee and Mack, Matthias and Triantafyllopoulou, Antigoni and Dunlap, Micah D. and Khader, Shabaana A. and Seidl, Maximilian and Hoelscher, Alexandra and Hoelscher, Christoph and Guan, Xue Li and Dorhoi, Anca and Henneke, Philipp (2021) Monocyte progenitors give rise to multinucleated giant cells. NATURE COMMUNICATIONS, 12 (1): 2027. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and cell autonomous cell cycle modifications. However, the giant cell progenitor identity remained unclear. Here, we show that the giant cell-forming potential is a particular trait of monocyte progenitors. Common monocyte progenitors potently produce cytokines in response to mycobacteria and their immune-active molecules. In addition, common monocyte progenitors accumulate cholesterol and lipids, which are prerequisites for giant cell transformation. Inducible monocyte progenitors are so far undescribed circulating common monocyte progenitor descendants with high giant cell-forming potential. Monocyte progenitors are induced in mycobacterial infections and localize to granulomas. Accordingly, they exhibit important immunological functions in mycobacterial infections. Moreover, their signature trait of high cholesterol metabolism may be piggy-backed by mycobacteria to create a permissive niche. Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Sep 2022 13:14 |
| Last Modified: | 27 Sep 2022 13:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48111 |
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