Roth, Mathias and Holtmann, Christoph and Daas, Loay and Kakkassery, Vinodh and Kurzai, Oliver and Geerling, Gerd and Baeurle, Sebastian and Bayoudh, Wesal and Bruecher, Viktoria and Cvetkova-Fischer, Nadezhda and Blak, Matthias Dias and Bornstein, Agnes and Fischer, Charlotte and Fuest, Matthias and Grisanti, Salvatore and Herwig-Carl, Martina C. and Kroll, Sandra and Lenk, Janine and Lommatzsch, Claudia and MacKenzie, Colin R. and Matthaei, Mario and Mehlan, Juliane and Messmer, Elisabeth M. and Mueller, Violetta and Pawlik, Vera and Ranjbar, Mahdy and Renner-Wilde, Anna and Rickmann, Annekatrin and Saeger, Mark and Schargus, Marc and Schwarz, Luisa and Seitz, Berthold and Steindor, Friedrich and Unterlauf, Jan Darius and Viestenz, Arne and von Lilienfeld-Toal, Marie and Walther, Grit (2021) Results From the German Fungal Keratitis Registry: Significant Differences Between Cases With and Without a History of Contact Lens Use. CORNEA, 40 (11). pp. 1453-1461. ISSN 0277-3740, 1536-4798
Full text not available from this repository. (Request a copy)Abstract
Purpose: Fungal keratitis (FK) is a serious ophthalmic disease with a potentially devastating outcome that seems to be increasing in recent years. The use of contact lenses (CLs) was evaluated as a risk factor for FK to determine possible differences in course and outcome. Methods: Data from 173 cases reported in the German FK registry until August 2019 were evaluated regarding CL behavior, other ophthalmological and general risk factors, age, sex, identified pathogens, conservative and surgical therapy, visual acuity, and findings at admission and follow-up. Results: One hundred seventy-four eyes from 173 patients between 2000 and 2019 were included [64.4% women, median age 54 (39; 72) years]; 49.7% wore CL, of which 81.3% were soft CL, and 50.3% had no history of contact lens use (NCL). CL users were significantly more often women and otherwise healthy (CL: 80.2% vs. NCL: 48.9%; P < 0.0001). The spectrum of pathogens among CL users showed a significantly higher proportion of infections with filamentous pathogens, in particular Fusarium sp. (total filament: CL 69.8% vs. NCL 27.3%; P = 0.0001; Fusarium sp.: CL 50.0% vs. NCL 14.8%; P < 0.0001). Overall, 54.6% required keratoplasty and 8.6% enucleation. Conclusions: CLS are the most important risk factor for FK in Germany. With CLs, typically, the infection is caused by molds, and patients are comparably younger and otherwise healthy. Often, extensive surgery is needed. To evaluate changes in the pathogen and resistance spectrum and to further monitor possible CL-related risk factors, a consistent collection of data remains paramount.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CLINICAL CHARACTERISTICS; BACTERIAL; FUSARIUM; LONDON; cornea; contact lens; risk factor; fungus; keratitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 04:43 |
| Last Modified: | 14 Sep 2022 04:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48133 |
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