Mayen, Ana-Lucia and Aglago, Elom K. and Knaze, Viktoria and Cordova, Reynalda and Schalkwijk, Casper G. and Wagner, Karl-Heinz and Aleksandrova, Krasimira and Fedirko, Veronika and Keski-Rahkonen, Pekka and Leitzmann, Michael F. and Katzke, Verena and Srour, Bernard and Schulze, Matthias B. and Masala, Giovanna and Krogh, Vittorio and Panico, Salvatore and Tumino, Rosario and Bueno-de-Mesquita, Bas and Brustad, Magritt and Agudo, Antonio and Chirlaque Lopez, Maria Dolores and Amiano, Pilar and Ohlsson, Bodil and Ramne, Stina and Aune, Dagfinn and Weiderpass, Elisabete and Jenab, Mazda and Freisling, Heinz (2021) Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study. INTERNATIONAL JOURNAL OF CANCER, 149 (4). pp. 854-864. ISSN 0020-7136, 1097-0215
Full text not available from this repository. (Request a copy)Abstract
Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n = 450 111). Dietary intake of three AGEs, N-epsilon-[carboxymethyl]lysine (CML), N-epsilon-[1-carboxyethyl]lysine (CEL) and N-delta-[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with the risk of HCC (per 1 SD increment, HR-(CML) = 0.87, 95% CI: 0.76-0.99, HR-(CEL) = 0.84, 95% CI: 0.74-0.96 and HR-(MH-G1) = 0.84, 95% CI: 0.74-0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-(CML) = 1.28, 95% CI: 1.05-1.56, HR-(CEL) = 1.17; 95% CI: 0.96-1.40, HR-(MH-G1) = 1.27, 95% CI: 1.06-1.54). No associations were observed for cancers of the intra and extrahepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; advanced glycation endproducts; bile duct cancers; EPIC study; gallbladder cancer; hepatocellular carcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2022 05:56 |
| Last Modified: | 04 Oct 2022 05:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48162 |
Actions (login required)
 |
View Item |
