Ostkamp, Patrick and Salmen, Anke and Pignolet, Beatrice and Goerlich, Dennis and Andlauer, Till F. M. and Schulte-Mecklenbeck, Andreas and Gonzalez-Escamilla, Gabriel and Bucciarelli, Florence and Gennero, Isabelle and Breuer, Johanna and Antony, Gisela and Schneider-Hohendorf, Tilman and Mykicki, Nadine and Bayas, Antonios and Bergh, Florian Then and Bittner, Stefan and Hartung, Hans-Peter and Friese, Manuel A. and Linker, Ralf A. and Luessi, Felix and Lehmann-Horn, Klaus and Muehlau, Mark and Paul, Friedemann and Stangel, Martin and Tackenberg, Bjorn and Tumani, Hayrettin and Warnke, Clemens and Weber, Frank and Wildemann, Brigitte and Zettl, Uwe K. and Ziemann, Ulf and Muller-Myhsok, Bertram and Kuempfel, Tania and Klotz, Luisa and Meuth, Sven G. and Zipp, Frauke and Hemmer, Bernhard and Hohlfeld, Reinhard and Brassat, David and Gold, Ralf and Gross, Catharina C. and Lukas, Carsten and Groppa, Sergiu and Loser, Karin and Wiendl, Heinz and Schwab, Nicholas (2021) Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118 (1): e201845711. ISSN 0027-8424,
Full text not available from this repository. (Request a copy)Abstract
Multiple sclerosis (MS) disease risk is associated with reduced sunexposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n(NationMS) = 946, n(BIONAT) = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-beta-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests benefidal effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VITAMIN-D; INTERFERON-BETA; I INTERFERON; 25-HYDROXYVITAMIN D; DISEASE-ACTIVITY; UV-RADIATION; SUN EXPOSURE; RECEPTOR; RISK; HORMONE; sunlight; multiple sclerosis; vitamin D; latitude; melanocortin 1 receptor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2022 05:33 |
| Last Modified: | 05 Jul 2022 05:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48213 |
Actions (login required)
 |
View Item |
