Kato, Ken and Cammann, Victoria L. and Napp, L. Christian and Szawan, Konrad A. and Micek, Jozef and Dreiding, Sara and Levinson, Rena A. and Petkova, Vanya and Wurdinger, Michael and Patrascu, Alexandru and Sumalinog, Rafael and Gili, Sebastiano and Clarenbach, Christian F. and Kohler, Malcolm and Wischnewsky, Manfred and Citro, Rodolfo and Vecchione, Carmine and Bossone, Eduardo and Neuhaus, Michael and Franke, Jennifer and Meder, Benjamin and Jaguszewski, Milosz and Noutsias, Michel and Knorr, Maike and Heiner, Susanne and D'Ascenzo, Fabrizio and Dichtl, Wolfgang and Burgdorf, Christof and Kherad, Behrouz and Tschope, Carsten and Sarcon, Annahita and Shinbane, Jerold and Rajan, Lawrence and Michels, Guido and Pfister, Roman and Cuneo, Alessandro and Jacobshagen, Claudius and Karakas, Mahir and Koenig, Wolfgang and Pott, Alexander and Meyer, Philippe and Roffi, Marco and Banning, Adrian and Wolfrum, Mathias and Cuculi, Florim and Kobza, Richard and Fischer, Thomas A. and Vasankari, Tuija and Airaksinen, K. E. Juhani and Budnik, Monika and Dworakowski, Rafal and MacCarthy, Philip and Kaiser, Christoph and Osswald, Stefan and Galiuto, Leonarda and Chan, Christina and Bridgman, Paul and Beug, Daniel and Delmas, Clement and Lairez, Olivier and Gilyarova, Ekaterina and Shilova, Alexandra and Gilyarov, Mikhail and El-Battrawy, Ibrahim and Akin, Ibrahim and Kozel, Martin and Tousek, Petr and Winchester, David E. and Galuszka, Jan and Ukena, Christian and Poglajen, Gregor and Carrilho-Ferreira, Pedro and Hauck, Christian and Paolini, Carla and Bilato, Claudio and Sano, Masanori and Ishibashi, Iwao and Takahara, Masayuki and Himi, Toshiharu and Kobayashi, Yoshio and Prasad, Abhiram and Rihal, Charanjit S. and Liu, Kan and Schulze, P. Christian and Bianco, Matteo and Jorg, Lucas and Rickli, Hans and Pestana, Goncalo and Nguyen, Thanh H. and Bohm, Michael and Maier, Lars S. and Pinto, Fausto J. and Widimsky, Petr and Felix, Stephan B. and Opolski, Grzegorz and Braun-Dullaeus, Ruediger C. and Rottbauer, Wolfgang and Hasenfuss, Gerd and Pieske, Burkert M. and Schunkert, Heribert and Borggrefe, Martin and Thiele, Holger and Bauersachs, Johann and Katus, Hugo A. and Horowitz, John D. and Di Mario, Carlo and Munzel, Thomas and Crea, Filippo and Bax, Jeroen J. and Luscher, Thomas F. and Ruschitzka, Frank and Ghadri, Jelena R. and Templin, Christian (2021) Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry. ESC HEART FAILURE, 8 (3). pp. 1924-1932. ISSN 2055-5822,
Full text not available from this repository. (Request a copy)Abstract
Aims Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33-3.38; P = 0.002). Conclusions The present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Takotsubo syndrome; Broken heart syndrome; Outcome; Acute respiratory insufficiency; Chronic obstructive pulmonary disease; InterTAK Registry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2022 10:08 |
| Last Modified: | 04 Oct 2022 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48230 |
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