El-Battrawy, Ibrahim and Cammann, Victoria L. and Kato, Ken and Szawan, Konrad A. and Di Vece, Davide and Rossi, Aurelio and Wischnewsky, Manfred and Hermes-Laufer, Julia and Gili, Sebastiano and Citro, Rodolfo and Bossone, Eduardo and Neuhaus, Michael and Franke, Jennifer and Meder, Benjamin and Jaguszewski, Milosz and Noutsias, Michel and Knorr, Maike and Heiner, Susanne and D'Ascenzo, Fabrizio and Dichtl, Wolfgang and Burgdorf, Christof and Kherad, Behrouz and Tschoepe, Carsten and Sarcon, Annahita and Shinbane, Jerold and Rajan, Lawrence and Michels, Guido and Pfister, Roman and Cuneo, Alessandro and Jacobshagen, Claudius and Karakas, Mahir and Koenig, Wolfgang and Pott, Alexander and Meyer, Philippe and Arroja, Jose David and Banning, Adrian and Cuculi, Florim and Kobza, Richard and Fischer, Thomas A. and Vasankari, Tuija and Airaksinen, K. E. Juhani and Napp, L. Christian and Budnik, Monika and Dworakowski, Rafal and MacCarthy, Philip and Kaiser, Christoph and Osswald, Stefan and Galiuto, Leonarda and Chan, Christina and Bridgman, Paul and Beug, Daniel and Delmas, Clement and Lairez, Olivier and Gilyarova, Ekaterina and Shilova, Alexandra and Gilyarov, Mikhail and Kozel, Martin and Tousek, Petr and Winchester, David E. and Galuszka, Jan and Ukena, Christian and Poglajen, Gregor and Carrilho-Ferreira, Pedro and Hauck, Christian and Paolini, Carla and Bilato, Claudio and Kobayashi, Yoshio and Prasad, Abhiram and Rihal, Charanjit S. and Liu, Kan and Schulze, P. Christian and Bianco, Matteo and Joerg, Lucas and Rickli, Hans and Pestana, Goncalo and Nguyen, Thanh H. and Boehm, Michael and Maier, Lars S. and Pinto, Fausto J. and Widimsky, Petr and Felix, Stephan B. and Opolski, Grzegorz and Braun-Dullaeus, Ruediger C. and Rottbauer, Wolfgang and Hasenfuss, Gerd and Pieske, Burkert M. and Schunkert, Heribert and Thiele, Holger and Bauersachs, Johann and Katus, Hugo A. and Horowitz, John D. and Di Mario, Carlo and Muenzel, Thomas and Crea, Filippo and Bax, Jeroen J. and Luescher, Thomas F. and Ruschitzka, Frank and Duru, Firat and Borggrefe, Martin and Ghadri, Jelena R. and Akin, Ibrahim and Templin, Christian (2021) Impact of Atrial Fibrillation on Outcome in Takotsubo Syndrome: Data From the International Takotsubo Registry. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10 (15): e014059. ISSN , 2047-9980
Full text not available from this repository. (Request a copy)Abstract
Background Atrial fibrillation (AF) is a major risk factor for mortality. The prevalence, clinical correlates, and prognostic impact of AF in Takotsubo syndrome (TTS) have not yet been investigated in a large patient cohort. This study aimed to investigate the prevalence, clinical correlates, and prognostic impact of AF in patients with TTS. Methods and Results Patients with TTS were enrolled from the International Takotsubo Registry, which is a multinational network with 26 participating centers in Europe and the United States. Patients were dichotomized according to the presence or absence of AF at the time of admission. Of 1584 patients with TTS, 112 (7.1%) had AF. The mean age was higher (P<0.001), and there were fewer women (P=0.046) in the AF than in the non-AF group. Left ventricular ejection fraction was significantly lower (P=0.001), and cardiogenic shock was more often observed (P<0.001) in the AF group. Both in-hospital (P<0.001) and long-term mortality (P<0.001) were higher in the AF group. Multivariable Cox regression analysis revealed that AF was independently associated with higher long-term mortality (hazard ratio, 2.31; 95% CI, 1.50-3.55; P<0.001). Among patients with AF on admission, 42% had no known history of AF before the acute TTS event, and such patients had comparable in-hospital and long-term outcomes compared with those with a history of AF. Conclusions In patients presenting with TTS, AF on admission is significantly associated with increased in-hospital and long-term mortality rates. Whether antiarrhythmics and/or cardioversion are beneficial in TTS with AF should thus be tested in a future trial. Registration URL: ; Unique identifier: NCT01947621.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MECHANOELECTRIC FEEDBACK; CARDIOMYOPATHY; INFARCTION; PROGNOSIS; EVENTS; atrial fibrillation; broken heart syndrome; outcome; Takotsubo syndrome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2022 10:15 |
| Last Modified: | 04 Oct 2022 10:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48232 |
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