Imori, Yoichi and Kato, Ken and Cammann, Victoria L. and Szawan, Konrad A. and Wischnewsky, Manfred and Dreiding, Sara and Wuerdinger, Michael and Schoenberger, Maximilian and Petkova, Vanya and Niederseer, David and Levinson, Rena A. and Di Vece, Davide and Gili, Sebastiano and Seifert, Burkhardt and Wakita, Masaki and Suzuki, Noriko and Citro, Rodolfo and Bossone, Eduardo and Heiner, Susanne and Knorr, Maike and Jansen, Thomas and Muenzel, Thomas and D'Ascenzo, Fabrizio and Franke, Jennifer and Sorici-Barb, Ioana and Katus, Hugo A. and Sarcon, Annahita and Shinbane, Jerold and Napp, L. Christian and Bauersachs, Johann and Jaguszewski, Milosz and Shiomura, Reiko and Nakamura, Shunichi and Takano, Hitoshi and Noutsias, Michel and Burgdorf, Christof and Ishibashi, Iwao and Himi, Toshiharu and Koenig, Wolfgang and Schunkert, Heribert and Thiele, Holger and Kherad, Behrouz and Tschope, Carsten and Pieske, Burkert M. and Rajan, Lawrence and Michels, Guido and Pfister, Roman and Mizuno, Shingo and Cuneo, Alessandro and Jacobshagen, Claudius and Hasenfuss, Gerd and Karakas, Mahir and Mochizuki, Hiroki and Pott, Alexander and Rottbauer, Wolfgang and Said, Samir M. and Braun-Dullaeus, Ruediger C. and Banning, Adrian and Isogai, Toshiaki and Kimura, Akihisa and Cuculi, Florim and Kobza, Richard and Fischer, Thomas A. and Vasankari, Tuija and Airaksinen, K. E. Juhani and Tomita, Yasuhiro and Budnik, Monika and Opolski, Grzegorz and Dworakowski, Rafal and MacCarthy, Philip and Kaiser, Christoph and Osswald, Stefan and Galiuto, Leonarda and Crea, Filippo and Dichtl, Wolfgang and Murakami, Tsutomu and Ikari, Yuji and Empen, Klaus and Beug, Daniel and Felix, Stephan B. and Delmas, Clement and Lairez, Olivier and Yamaguchi, Tetsuo and El-Battrawy, Ibrahim and Akin, Ibrahim and Borggrefe, Martin and Horowitz, John D. and Kozel, Martin and Tousek, Petr and Widimsky, Petr and Gilyarova, Ekaterina and Shilova, Alexandra and Gilyarov, Mikhail and Neuhaus, Michael and Meyer, Philippe and Arroja, Jose David and Chan, Christina and Bridgman, Paul and Galuszka, Jan and Poglajen, Gregor and Carrilho-Ferreira, Pedro and Pinto, Fausto J. and Hauck, Christian and Maier, Lars S. and Liu, Kan and Di Mario, Carlo and Paolini, Carla and Bilato, Claudio and Bianco, Matteo and Joerg, Lucas and Rickli, Hans and Winchester, David E. and Ukena, Christian and Boehm, Michael and Bax, Jeroen J. and Prasad, Abhiram and Rihal, Charanjit S. and Saito, Shigeru and Kobayashi, Yoshio and Luscher, Thomas F. and Ruschitzka, Frank and Shimizu, Wataru and Ghadri, Jelena R. and Templin, Christian (2022) Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry. CLINICAL RESEARCH IN CARDIOLOGY, 111 (2). pp. 186-196. ISSN 1861-0684, 1861-0692
Full text not available from this repository. (Request a copy)Abstract
Background Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients. Results A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 +/- 11.4 years vs. 68.0 +/- 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p< 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p< 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients. Conclusion Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPERATING CHARACTERISTIC CURVES; IN-HOSPITAL MORTALITY; CARDIOMYOPATHY; DISPARITIES; RISK; Takotsubo syndrome; Broken heart syndrome; Ethnicity; Race |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2022 10:26 |
| Last Modified: | 04 Oct 2022 10:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48235 |
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