Wang, Heming and Noordam, Raymond and Cade, Brian E. and Schwander, Karen and Winkler, Thomas W. and Lee, Jiwon and Sung, Yun Ju and Bentley, Amy R. and Manning, Alisa K. and Aschard, Hugues and Kilpelainen, Tuomas O. and Ilkov, Marjan and Brown, Michael R. and Horimoto, Andrea R. and Richard, Melissa and Bartz, Traci M. and Vojinovic, Dina and Lim, Elise and Nierenberg, Jovia L. and Liu, Yongmei and Chitrala, Kumaraswamynaidu and Rankinen, Tuomo and Musani, Solomon K. and Franceschini, Nora and Rauramaa, Rainer and Alver, Maris and Zee, Phyllis C. and Harris, Sarah E. and van Der Most, Peter J. and Nolte, Ilja M. and Munroe, Patricia B. and Palmer, Nicholette D. and Kuhnel, Brigitte and Weiss, Stefan and Wen, Wanqing and Hall, Kelly A. and Lyytikainen, Leo-Pekka and Connell, Jeff O. and Eiriksdottir, Gudny and Launer, Lenore J. and de Vries, Paul S. and Arking, Dan E. and Chen, Han and Boerwinkle, Eric and Krieger, Jose E. and Schreiner, Pamela J. and Sidney, Stephen and Shikany, James M. and Rice, Kenneth and Chen, Yii-Der Ida and Gharib, Sina A. and Bis, Joshua C. and Luik, Annemarie and Ikram, M. Arfan and Uitterlinden, Andre G. and Amin, Najaf and Xu, Hanfei and Levy, Daniel and He, Jiang and Lohman, Kurt K. and Zonderman, Alan B. and Rice, Treva K. and Sims, Mario and Wilson, Gregory and Sofer, Tamar and Rich, Stephen S. and Palmas, Walter and Yao, Jie and Guo, Xiuqing and Rotter, Jerome and Biermasz, Nienke R. and Mook-Kanamori, Dennis O. and Martin, Lisa W. and Barac, Ana and Wallace, Robert B. and Gottlieb, Daniel J. and Komulainen, Pirjo and Heikkinen, Sami and Magi, Reedik and Milani, Lili and Metspalu, Andres and Starr, John M. and Milaneschi, Yuri and Waken, R. J. and Gao, Chuan and Waldenberger, Melanie and Peters, Annette and Strauch, Konstantin and Meitinger, Thomas and Roenneberg, Till and Volker, Uwe and Dorr, Marcus and Shu, Xiao-Ou and Mukherjee, Sutapa and Hillman, David R. and Kahonen, Mika and Wagenknecht, Lynne E. and Gieger, Christian and Grabe, Hans J. and Zheng, Wei and Palmer, Lyle J. and Lehtimaki, Terho and Gudnason, Vilmundur and Morrison, Alanna C. and Pereira, Alexandre C. and Fornage, Myriam and Psaty, Bruce M. and van Duijn, Cornelia M. and Liu, Ching-Ti and Kelly, Tanika N. and Evans, Michele K. and Bouchard, Claude and Fox, Ervin R. and Kooperberg, Charles and Zhu, Xiaofeng and Lakka, Timo A. and Esko, Tonu and North, Kari E. and Deary, Ian J. and Snieder, Harold and Penninx, Brenda W. J. H. and Gauderman, W. James and Rao, Dabeeru C. and Redline, Susan and van Heemst, Diana (2021) Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. MOLECULAR PSYCHIATRY, 26 (11). pp. 6293-6304. ISSN 1359-4184, 1476-5578
Full text not available from this repository. (Request a copy)Abstract
Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 P-joint < 5 x 10(-8)), including rs7955964 (FIGNL2/ANKRD33) that increases BP among long sleepers, and rs73493041 (SNORA26/C9orf170) and rs10406644 (KCTD15/LSM14A) that increase BP among short sleepers (P-int < 5 x 10(-8)). Secondary ancestry-specific analysis identified another novel gene by long sleep interaction at rs111887471 (TRPC3/KIAA1109) in individuals of African ancestry (P-int = 2 x 10(-6)). Combined stage 1 and 2 analyses additionally identified significant gene by long sleep interactions at 10 loci including MKLN1 and RGL3/ELAVL3 previously associated with BP, and significant gene by short sleep interactions at 10 loci including C2orf43 previously associated with BP (P-int < 10(-3)). 2df test also identified novel loci for BP after modeling sleep that has known functions in sleep-wake regulation, nervous and cardiometabolic systems. This study indicates that sleep and primary mechanisms regulating BP may interact to elevate BP level, suggesting novel insights into sleep-related BP regulation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BODY-MASS INDEX; ASSOCIATION ANALYSIS; NATIONAL-HEALTH; DURATION; METAANALYSIS; VARIANTS; COMMON; TRAITS; RISK; IDENTIFICATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2022 12:41 |
| Last Modified: | 04 Oct 2022 12:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48242 |
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