Hoerauf, K. H. and Wiesner, G. and Schroegendorfer, K. F. and Jobst, B. P. and Spacek, A. and Harth, M. and Sator-Katzenschlager, S. and Ruediger, H. W. (1999) Waste anaesthetic gases induce sister chromatid exchanges in lymphocytes of operating room personnel. BRITISH JOURNAL OF ANAESTHESIA, 82 (5). pp. 764-766. ISSN 0007-0912,
Full text not available from this repository.Abstract
Genotoxicity related to waste anaesthetic gas exposure is controversial. We have investigated the frequency of sister chromatid exchanges in peripheral lymphocytes of operating room personnel exposed to trace concentrations of isoflurane and nitrous oxide. Occupational exposure was recorded using a direct reading instrument. Frequencies of sister chromatid exchanges were measured in lymphocyte cultures of 27 non-smokers working in the operating room and 27 non-smoking controls. Personnel were exposed to an 8-h time-weighted average of nitrous oxide 11.8 ppm and isoflurane 0.5 ppm. After exposure, sister chromatid exchange frequency was increased significantly (mean 9.0 (SD 1.3) vs 8.0 (1.4) in exposed and control personnel, respectively) (P<0.05). We conclude that exposure to even trace concentrations of waste anaesthetic gases may cause genetic damage comparable with smoking 11-20 cigarettes per day.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; anaesthetics volatile, trace concentrations; anaesthetics gases, trace concentrations; genetic factors; operating rooms, contamination; anaesthetist, risks |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Oct 2022 13:33 |
| Last Modified: | 19 Oct 2022 13:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48263 |
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