Kumar, Sunil and Mueller, Klaus (1999) Inhibition of keratinocyte growth by different nepalese Zanthoxylum species. PHYTOTHERAPY RESEARCH, 13 (3). pp. 214-217. ISSN 0951-418X,
Full text not available from this repository.Abstract
A total of 11 methanol extracts obtained from Pour different Nepalese Zanthoxylum species were screened for their antiproliferative activity against the growth of human keratinocytes (HaCaT cells). The extract obtained from Z. armatum barks was highly active with an IC50 value of 11 mu g/mL. Also, the extracts obtained from Z. oxyphyllum barks and roots with IC50 values of 53 and 57 mu g/mL, respectively, showed potent activity. Their antiproliferative activity was not due to cytotoxic effects on cell membranes, as documented by the activity of lactate dehydrogenase released from the cytoplasm of keratinocytes, which did not exceed that of the control value. Rather, they also protected against radical-induced damage to model membranes stimulated with 2,2'-azo-bis(2-amidinopropane) dihydrochloride. Copyright (C) 1999 John Wiley & Sons, Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIPSORIATIC MAHONIA-AQUIFOLIUM; MODULATED REDOX PROPERTIES; ANTIPROLIFERATIVE ACTIVITY; 5-LIPOXYGENASE; CONSTITUENTS; ALKALOIDS; BENZOPHENANTHRIDINE; INTEGRIFOLIOLUM; AGGREGATION; DERIVATIVES; Zanthoxylum; Rutaceae; antiproliferative activity; HaCaT cells; Nepalese plants; skin diseases |
| Subjects: | 600 Technology > 620 Engineering & allied operations |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Oct 2022 13:56 |
| Last Modified: | 25 Oct 2022 13:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48306 |
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