Wilisch, A. and Gutsche, S. and Hoffacker, V. and Schultz, A. and Tzartos, S. and Nix, W. and Schalke, B. and Schneider, C. and Muller-Hermelink, H.K. and Marx, A. (1999) Association of acetylcholine receptor alpha-subunit gene expression in mixed thymoma with myasthenia gravis. NEUROLOGY, 52 (7). pp. 1460-1466. ISSN 0028-3878,
Full text not available from this repository.Abstract
Objective: To investigate the association of MG with the transcription of muscular or neuronal acetylcholine receptor (AChR) subunit genes in thymomas. Background: Many steps in the pathogenesis of MG have been elucidated but, with rare exceptions, its etiology is unknown. In patients with MG with thymoma, the tumor probably elicits autoimmunity to AChR, but it is enigmatic why MG develops in some patients but not in others. Methods: Reverse transcriptase (RT)-PCR, immunohistochemistry, and immunofluorescence studies were carried out to investigate AChR expression in 35 patients with thymoma. Statistical analysis was used to specify significant differences between thymoma subtypes. Results: Considering all thymomas (n = 35), no correlation was found between MG status and AChR gene expression as detected by RT-PCR. However, when histologically defined thymoma subtypes were studied separately, transcription of the muscular AChR P3A(-) or-subunit gene was significantly associated (alpha < 0.01) with the occurrence of MG in mixed thymomas (n = 17), but not in thymomas of the cortical type. For the other muscular AChR subunits (P3A(+) alpha isoform, beta, gamma, delta, and epsilon) and the alpha(2) and beta(4) neuronal AChR subunits, no such correlation was detected. Conclusions: Expression of the P3A- AChR or-subunit gene might be important for the pathogenesis of MG in mixed thymomas, suggesting etiologic heterogeneity of paraneoplastic MG among patients with histologically different thymoma subtypes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THYMIC EPITHELIAL TUMORS; MONOCLONAL-ANTIBODIES; TRANSGENIC MICE; MYOID CELLS; T-CELLS; MUSCLE; PATHOGENESIS; ISOFORMS; MICROENVIRONMENT; TOLERANCE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Nov 2022 09:14 |
| Last Modified: | 07 Nov 2022 09:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48316 |
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