Funk, Wolfgang and Roth, G. and Gruber, M. and Hobbhahn, J. (1999) Carbon-monoxide hemoglobin during inhalation anaesthesia - A new problem? ANASTHESIOLOGIE & INTENSIVMEDIZIN, 40 (4). pp. 195-200. ISSN 0170-5334,
Full text not available from this repository. (Request a copy)Abstract
Generation of carbon monoxide within rebreathing circuits using enflurane has been reported. Also with isoflurane, halothane and the recently introduced desflurane and sevoflurane, CO has been found in circle systems. This review discusses the sources of CO in anaesthesia circle systems, the toxicology of CO and possible precautions to minimize exposure. The main source is the patient. A normal range of 0.4 - 10% of GO-hemoglobin comes from hemoglobin degradation, environmental pollution and smoking. The only pathogenetic mechanism of GO-poisoning is tissue due to a reduced oxygen carrying capacity. Meaningful formation of CO in anaesthesia circles occurs only,vith excessively dried soda lime during Enflurane, Desflurane or Isoflurane anaesthesia. Accumulation with low fresh gas flow and in closed circles is not of importance, since low flow conditions keep the soda lime wet and cool thus preventing degradation of volatile anaesthetics. The toxicologically critical threshold of 250 ppm is exceeded only at levels of dryness rarely attained in clinical situations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CLOSED-SYSTEM ANESTHESIA; DRY SODA LIME; VOLATILE ANESTHETICS; DIOXIDE ABSORBENTS; DEGRADATION; CARBOXYHEMOGLOBIN; SEVOFLURANE; ISOFLURANE; TEMPERATURE; ABSORPTION; anaesthesia; carbon monoxide; carbon dioxide; absorption |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Nov 2022 10:46 |
| Last Modified: | 08 Nov 2022 10:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48344 |
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