Trzonkowski, Piotr and Bacchetta, Rosa and Battaglia, Manuela and Berglund, David and Bohnenkamp, Hermann Richard and ten Brinke, Anja and Bushell, Andrew and Cools, Nathalie and Geissler, Edward K. and Gregori, Silvia and van Ham, S. Marieke and Hilkens, Catharien and Hutchinson, James A. and Lombardi, Giovanna and Madrigal, J. Alejandro and Marek-Trzonkowska, Natalia and Martinez-Caceres, Eva M. and Roncarolo, Maria Grazia and Sanchez-Ramon, Silvia and Saudemont, Aurore and Sawitzki, Birgit (2015) Hurdles in therapy with regulatory T cells. SCIENCE TRANSLATIONAL MEDICINE, 7 (304): 304ps18. ISSN 1946-6234, 1946-6242
Full text not available from this repository. (Request a copy)Abstract
Improper activation of the immune system contributes to a variety of clinical conditions, including autoimmune and allergic diseases as well as solid organ and bone marrow transplantation. One approach to counteract this activation is through adoptive therapy with regulatory T cells (T-regs). Efforts to manufacture these cells have led to good maunfacturing practice-compliant protocols, and T-reg products are entering early clinical trials. Here, we report the stance of the European Union Cooperation in Science and Technology Action BM1305, "Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies-A FACTT," which identifies hurdles hindering T-reg clinical applications in Europe and provides possible solutions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EX-VIVO; ADOPTIVE TRANSFER; PANCREATIC-ISLETS; PERIPHERAL-BLOOD; TREG EXPANSION; HOST-DISEASE; TRANSPLANTATION; PREVENTION; TOLERANCE; IMMUNOTHERAPY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jun 2019 09:49 |
| Last Modified: | 07 Jun 2019 09:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4836 |
Actions (login required)
 |
View Item |
