Schling, P. and Mallow, H. and Trindl, A. and Loeffler, Georg (1999) Evidence for a local renin angiotensin system in primary cultured human preadipocytes. INTERNATIONAL JOURNAL OF OBESITY, 23 (4). pp. 336-341. ISSN 0307-0565, 1476-5497
Full text not available from this repository.Abstract
OBJECTIVE: To investigate whether human preadipocytes possess a complete functional renin angiotensin system. MEASUREMENTS: Gene expression of angiotensinogen, renin, renin binding protein, angiotensin converting enzyme (ACE) and angiotensin II (ang II) receptor type 1 in human preadipocytes; ACE protein and ang II production of human adipose tissue stromal cells differentiated or not in primary culture. RESULTS: All genes mentioned above were found to be expressed in human preadipocytes. ACE was translated into protein as detected by western blot. Ang II was secreted both by undifferentiated preadipocytes and immature adipocytes, and its production was significantly elevated in differentiated cells. CONCLUSIONS: Preadipocytes from human adipose tissue express a functional renin angiotensin system (RAS).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-EXPRESSION; MOLECULAR-CLONING; SEQUENCE-ANALYSIS; ADIPOSE-TISSUE; II RECEPTOR; CELLS; DIFFERENTIATION; BINDING; ADIPOCYTES; PROMOTER; renin angiotensin system; gene expression; angiotensin II; human preadipocytes |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Nov 2022 13:43 |
| Last Modified: | 08 Nov 2022 13:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48403 |
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