Chiral 1,3-diamines from a lithiated isocyanide and chiral aziridines

Kaiser, Alexander and Balbi, Miriam (1999) Chiral 1,3-diamines from a lithiated isocyanide and chiral aziridines. TETRAHEDRON-ASYMMETRY, 10 (5). pp. 1001-1014. ISSN 0957-4166,

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Abstract

Reaction of lithiated 4-methoxybenzylisocyanide with homochiral amino acid derived N-tosyl- and N-diphenylphosphinoylaziridines proceeds diastereoselectively to provide N-protected 3-isocyanoamines. Separation of the diastereomers of these adducts or the corresponding formamides, and subsequent transformations, lead to 1,3-diamines and their monoprotected and differentially bisprotected derivatives. (C) 1999 Elsevier Science Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: REDUCTION;
Subjects: 600 Technology > 615 Pharmacy
Divisions: Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 15 Nov 2022 07:11
Last Modified: 15 Nov 2022 07:11
URI: https://pred.uni-regensburg.de/id/eprint/48438

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