Muders, Frank and Elsner, Dietmar and Schunkert, Heribert and Riegger, Guenter A. J. and Palkovits, Miklos (1999) Central vasopressin is modulated by chronic blockade of the renin-angiotensin system in experimental left ventricular hypertrophy. AMERICAN JOURNAL OF HYPERTENSION, 12 (3). pp. 311-314. ISSN 0895-7061,
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We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT(1) receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT(1) antagonists. Am J Hypertens 1999;12:311-314 (C) 1999 American Journal of Hypertension, Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAT-BRAIN; vasopressin; brain nuclei; ventricular hypertrophy; aortic banding; angiotensin-converting enzyme; angiotensin II |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2022 07:52 |
| Last Modified: | 15 Nov 2022 07:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48442 |
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