Van Praag, Henriette and Kempermann, Gerd and Gage, Fred H. (1999) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. NATURE NEUROSCIENCE, 2 (3). pp. 266-270. ISSN 1097-6256,
Full text not available from this repository.Abstract
Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate components by assigning adult mice to various conditions: water-maze learning (learner), swim-time-yoked control (swimmer), voluntary wheel running (runner), and enriched (enriched) and standard housing (control) groups. Neither maze training nor yoked swimming had any effect on bromodeoxyuridine (BrdU)-positive cell number. However, running doubled the number of surviving newborn cells, in amounts similar to enrichment conditions. Our findings demonstrate that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FIBROBLAST GROWTH-FACTOR; HIPPOCAMPAL THETA-RHYTHM; RAT HIPPOCAMPUS; ENRICHED ENVIRONMENT; SPATIAL MEMORY; MESSENGER-RNA; NEURONS; BRAIN; EXPERIENCE; FOREBRAIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2022 13:33 |
| Last Modified: | 15 Nov 2022 13:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48481 |
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