Gust, Ronald and Heinrich, H. and Krauser, Rudolf and Schoenenberger, Helmut (1999) [Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinyl-bis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities. INORGANICA CHIMICA ACTA, 285 (2). pp. 184-189. ISSN 0020-1693,
Full text not available from this repository. (Request a copy)Abstract
The synthesis, the physiochemical and the breast cancer inhibiting properties of [meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chlorides(meso- and rac-4F-PtCl(DMSO)) are described, Rac-4F-PtCl(DMSO) surpasses the standard carboplatin in its effect on the human MCF-7 breast cancer cell line and is more resistant than its: dichloroplatinum(II) analogue rac-4F-PtCl2 against attack of nucleophiles, a prerequisite for sufficient stability in physiological environments and consequently for marked antitumor activity in vivo. [GRAPHICS] (C) 1999 Elsevier Science S.A. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTITUMOR-ACTIVITY; <1,2-BIS(2,6-DIHALO-3-HYDROXYPHENYL)ETHYLENEDIAMINE>PLATINUM(II) COMPLEXES; BIOLOGICAL-ACTIVITY; ANTICANCER DRUGS; DIMETHYLSULFOXIDE; SULFOXIDES; MECHANISM; antitumor activity; platinum complexes; diammine complexes; sulfinyl complexes |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Nov 2022 08:53 |
| Last Modified: | 21 Nov 2022 08:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48518 |
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