Hoerauf, K. H. and Schroegendorfer, K. F. and Wiesner, G. and Gruber, M. and Spacek, A. and Kress, H. G. and Ruediger, H. W. (1999) Sister chromatid exchange in human lymphocytes exposed to isoflurane and nitrous oxide in vitro. BRITISH JOURNAL OF ANAESTHESIA, 82 (2). pp. 268-270. ISSN 0007-0912,
Full text not available from this repository.Abstract
The question of whether or nor inhalation anaesthetics are genotoxic remains controversial. Therefore, we have studied the in vitro genotoxic potential of isoflurane and nitrous oxide in human lymphocytes. Blood samples were obtained from eight healthy male, non-smelting volunteers, which were incubated and exposed to increasing concentrations of isoflurane (0.0, 0.3, 0.6 and 1.2 mmol litre(-1)) or 50% nitrous oxide in oxygen. Baseline sister chromatid exchange (SCE) rate per cell was mean 7.65 (SD 1.5) which increased to 9.15 (1.0), 9.55 (1.4) and 9.95 (1.8) SCE/cell during exposure to isoflurane 0.3, 0.6 and 1.2 mmol litre(-1), respectively. During 50% nitrous oxide exposure, SCE rate was 9.26 (1.4). The difference between the control and exposed cells was statistically significant (P less than or equal to 0.05). We conclude that exposure to nitrous oxide and subanaesthetic concentrations of isoflurane can produce genetic damage in peripheral lymphocytes in vitro.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MUTAGENICITY; ANESTHETICS; anaesthetics volatile, isoflurane; anaesthetics gases, nitrous oxide; genetic factors, anaesthetics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Nov 2022 08:15 |
| Last Modified: | 22 Nov 2022 08:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48538 |
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