Mueller-Ladner, Ulf and Bosserhoff, Anja-Katrin and Dreher, K. and Hein, R. and Neidhart, M. and Gay, S. and Schoelmerich, Juergen and Buettner, R. and Lang, B. (1999) MIA (melanoma inhibitory activity): a potential serum marker for rheumatoid arthritis. RHEUMATOLOGY, 38 (2). pp. 148-154. ISSN 1462-0324, 1462-0332
Full text not available from this repository.Abstract
Objective. MIA (melanoma inhibitory activity) is correlated with metastasis in patients with malignant melanoma. As MIA is not only produced by melanoma cells, but also by differentiated chondrocytes, we examined whether serum levels of MIA are correlated with inflammation and/or joint destruction in rheumatic diseases. Methods. MIA serum concentrations of patients with different rheumatic diseases were examined and compared with healthy individuals and malignant melanoma patients. In addition, MIA concentrations were correlated to inflammatory parameters and joint destruction. Results. Increased MIA serum concentrations were found only in patients with rheumatic diseases associated with joint destruction, such as rheumatoid arthritis (RA), osteoarthritis, HLA B27-associated oligoarthritis, and psoriatic arthritis. Of these rheumatic diseases, a significant increase in MIA serum concentrations was seen only in patients with RA, associated with rheumatoid factor (RF) positivity and joint destruction. Conclusions. In addition to RF, MIA might therefore be useful in the differential diagnosis of RA vs non-destructive rheumatic diseases, and the presence of elevated levels of MIA in serum very likely reflects joint destruction in RA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-SITU HYBRIDIZATION; FACTOR-KAPPA-B; CYSTEINE PROTEINASE; MALIGNANT-MELANOMA; ARTICULAR-CARTILAGE; GROWTH-FACTORS; CATHEPSIN-H; CELL-LINES; EXPRESSION; GENE; MIA; rheumatoid arthritis; rheumatoid factor; joint destruction; cartilage |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Nov 2022 14:09 |
| Last Modified: | 22 Nov 2022 14:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48570 |
Actions (login required)
 |
View Item |
