Schiessl, Ina Maria and Castrop, Hayo (2015) Regulation of NKCC2 splicing and phosphorylation. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 24 (5). pp. 457-462. ISSN 1062-4821, 1473-6543
Full text not available from this repository. (Request a copy)Abstract
Purpose of reviewTransepithelial salt transport in the thick ascending limb of Henle's loop (TAL) crucially depends on the activity of the Na/K/2Cl cotransporter NKCC2. The pharmacologic blockade of NKCC2 leads to pronounced natriuresis and diuresis, which indicate key roles for NKCC2 in renal salt retrieval. The inadequate regulation of NKCC2 and the loss of NKCC2 function are associated with the disruption of salt and water homoeostasis. This review provides a specific overview of our current knowledge with respect to the regulation of NKCC2 by differential splicing and phosphorylation.Recent findingsSeveral mechanisms have evolved to adapt NKCC2 transport to reabsorptive needs. These mechanisms include the regulation of NKCC2 gene expression, the differential splicing of the NKCC2 pre-mRNA, the membrane trafficking, and the modulation of the specific transport activity. Substantial progress has been made over the past few years in deciphering the function of kinases in the regulatory network controlling NKCC2 activity and in elucidating the underlying mechanism and the functional consequences of the regulated differential splicing of the NKCC2 pre-mRNA.SummaryNKCC2 differential splicing and phosphorylation are critically involved in the modulation of the thick ascending limb of Henle's loop reabsorptive capacity and, consequently, in salt homoeostasis, volume regulation, and blood pressure control.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THICK ASCENDING LIMB; K-CL COTRANSPORTER; MACULA DENSA CELLS; ACTIVATED PROTEIN-KINASE; NA-K-2CL COTRANSPORTER; NA+-K+-2CL(-) COTRANSPORTER; FUNCTIONAL-CHARACTERIZATION; MOLECULAR-CLONING; RENIN SECRETION; BLOOD-PRESSURE; differential splicing; NKCC2; Slc12a1; splice isoforms; transporter phosphorylation and trafficking |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Aug 2020 10:47 |
| Last Modified: | 25 Aug 2020 10:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4858 |
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