Strahl-Bolsinger, Sabine and Gentzsch, Martina and Tanner, Widmar (1999) Protein O-mannosylation. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1426 (2). pp. 297-307. ISSN 0304-4165, 1872-8006
Full text not available from this repository.Abstract
Protein O-mannosylation, originally observed in fungi, starts at the endoplasmic reticulum with the transfer of mannose from dolichyl activated mannose to seryl or threonyl residues of secretory proteins. This reaction is catalyzed by a family of protein O-mannosyltransferases (PMTs), which were first characterized in Saccharomyces cerevisiae. The identification of this evolutionarily conserved PMT gene family has led to the finding that protein O-mannosylation plays an essential role in a number of physiologically important processes. Focusing on the PMT gene family, we discuss here the main aspects of the biogenesis of O-linked carbohydrate chains in S. cerevisiae, Candida albicans, and other fungi. We summarize recent work utilizing pmt mutants that demonstrates the impact of protein O-mannosylation on protein secretion, on maintenance of cell wall integrity, and on budding. Further, the occurrence of PMT orthologs in higher eukaryotes such as Arabidopsis, Drosophila and mammals is reported and discussed. (C) 1999 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHOSPHATE MANNOSE SYNTHASE; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; CHONDROITIN SULFATE PROTEOGLYCAN; YEAST GLYCOPROTEIN-BIOSYNTHESIS; LIPID-LINKED OLIGOSACCHARIDE; BUD-SITE SELECTION; SACCHAROMYCES-CEREVISIAE; CANDIDA-ALBICANS; CELL-WALL; GENE FAMILY; O-glycosylation; mannosyltransferase; Dol-P-Man; PMT gene family; (Saccharomyces cerevisiae); (Candida albicans) |
| Subjects: | 500 Science > 580 Botanical sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften > Lehrstuhl für Zellbiologie und Pflanzenphysiologie (Prof. Dr. Klaus Grasser) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Nov 2024 09:19 |
| Last Modified: | 07 Nov 2024 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48587 |
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