Weiss, Katharina T. and Fante, Matthias and Koehl, Gudrun and Schreml, Julia and Haubner, Frank and Kreutz, Marina and Haverkampf, Sonja and Berneburg, Mark and Schreml, Stephan (2017) Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing. EXPERIMENTAL DERMATOLOGY, 26 (2). pp. 127-132. ISSN 0906-6705, 1600-0625
Full text not available from this repository. (Request a copy)Abstract
Dysregulation of pH is a feature of both tumor growth and tissue repair. In tumors, microenvironmental changes, like in lactate metabolism, lead to altered intra- and extracellular pH (pHi, pHe) and vice versa. In wounds, barrier disruption results in extensive variations in pHe on the wound surface. It is known that altered extracellular proton concentrations have a major impact on cell turnover and migration as well as on the metabolic activity of cells involved in tumor spread and wound closure. The proton-sensing G protein-coupled receptors (GPCRs) GPR4, GPR65 (TDAG8), GPR68 (OGR1) and GPR132 (G2A) are activated via a decrease in pHe and transduce this signal to molecular intracellular pathways. Based on the current knowledge, we speculate on the role of proton-sensing GPCRs in wound healing and on their potential as mechanistic linkers of tumor growth and tissue repair.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RETRACTED ARTICLE. SEE; AIRWAY SMOOTH-MUSCLE; EXTRACELLULAR PH; LACTIC-ACID; PERITONEAL-MACROPHAGES; CANCER PREVENTION; PROSTATE-CANCER; MICE DEFICIENT; SKIN PH; TDAG8; proton signalling; tissue repair; tumor metabolism; wounds |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 20 Oct 2020 10:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/486 |
Actions (login required)
 |
View Item |
