Kirchhof, Susanne and Goepferich, Achim M. and Brandl, Ferdinand P. (2015) Hydrogels in ophthalmic applications. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 95B. pp. 227-238. ISSN 0939-6411, 1873-3441
Full text not available from this repository. (Request a copy)Abstract
More and more people worldwide are affected by severe eye diseases eventually leading to visual impairment or blindness. In most cases, the treatment involves the application of ophthalmic dosage forms such as eye drops, suspensions or ointments. Unfortunately, some of the therapeutic approaches have major shortcomings, especially in the treatment of the posterior segment of the eye, where many vision-threatening diseases originate. Therefore, research focuses on the development of new materials (e.g., for vitreous substitution) and more advanced drug delivery systems. Hydrogels are an extremely versatile class of materials with many potential applications in ophthalmology. They found widespread application as soft contact lenses, foldable intraocular lenses, in situ gelling formulations for ophthalmic drug delivery and ocular adhesives for wound repair; their use as vitreous substitutes and intravitreal drug delivery systems is currently under investigation. In this article, we review the different applications of hydrogels in ophthalmology with special emphasis placed on the used polymers and their suitability as ocular drug delivery systems. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OCULAR DRUG-DELIVERY; ENDOTHELIAL GROWTH-FACTOR; TERM VITREOUS SUBSTITUTE; CROSS-LINKED HYDROGEL; IN-VITRO EVALUATION; MACULAR DEGENERATION; INTRAOCULAR LENSES; CONTROLLED-RELEASE; STEM-CELLS; POSTERIOR SEGMENT; Hydrogels; Ophthalmology; Drug delivery; Polymers; Contact lenses; Intraocular lenses; Vitreous substitutes; Tissue engineering |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Aug 2020 09:46 |
| Last Modified: | 25 Aug 2020 09:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4869 |
Actions (login required)
 |
View Item |
