Guba, M. and Bosserhoff, Anja-Katrin and Steinbauer, M. and Abels, C. and Anthuber, M. and Buettner, R. and Jauch, Karl-Walter (1999) MIA enhances liver metastasis of A-mel 3 melanoma cells. LANGENBECKS ARCHIVES OF SURGERY. pp. 601-603. ISSN 1435-2443,
Full text not available from this repository.Abstract
Introduction: Melanoma inhibitory activity (MIA) a 11 KD Protein expressed by melanoma cells is proposed to affect migration and invasion of melanoma cells. We therefore further investigated the role of MIA in the metastatic process of A-mel 3 melanoma cells. Methods: A-mel 3 cells with different levels of MIA expression were established by stable transfection with rhMIAcDNA. Tumor cell attachment, extravasation and metastasis were assessed by means of intravital microscopy. Liver metastasis after intraportal injection of variant A-mel 3 subclones was determinated by counting superficial tumor nodes. Results: Overexpression of rhMIA in A-mel 3 melanoma cells enhanced extravasation and liver metastasis of A-mel 3 cells in vivo. Conclusion: We therefore conclude, that MIA promotes liver metastases by facilitating extravasation and migration of melanoma cells in the liver.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MALIGNANT-MELANOMA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2022 10:11 |
| Last Modified: | 30 Nov 2022 10:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48691 |
Actions (login required)
 |
View Item |
