Steinbauer, M. and Guba, M. and Buchner, M. and Froehlich, D. and Farkas, S. and Jauch, Karl-Walter and Anthuber, M. (1999) Influence of ACE and AT(1)-receptor inhibition on the ischemia/reperfusion induced leukocyte adherence. LANGENBECKS ARCHIVES OF SURGERY. pp. 687-689. ISSN 1435-2443,
Full text not available from this repository.Abstract
Introduction: Enalapril has been shown to attenuate I/R injury. Aim of this study is to characterize the role and possible mechanisms of ACE and AT(1) receptor inhibition in I/R injury. Methods: Using intravital microscopy in a model of a 4 h tourniquet ischemia in the hamster dorsal skinfold chamber leukocyte endothelium interaction after application of 5 mg/kg Enalapril or Losartan was examined. Furthermore leukocyte adhesion and ICAM-1/VCAM-1 expression on HUVECs after hypoxial/reoxygenation was determined. Results: We could demonstrate that ACE inhibiton by enalapril - in contrast to AT(1)-receptor inhibiton - reduced the postischemic leukocyte adhesion. Furthermore Enalapril inhibited the hypoxia induced endothelial ICAM-1 and VCAM-1 expression and leukocyte adherence in a HUVEC model in the absence of Angiotensinogen. Conclusion: Taken together this suggests a pharmacologic effect of Enalapril on the NF-kappa B regulated neutrophil cytokine and endothelial adhesion molecule expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONVERTING ENZYME-INHIBITION; KAPPA-B ACTIVATION; ENALAPRIL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2022 10:14 |
| Last Modified: | 30 Nov 2022 10:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48692 |
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