Hennig, Robert and Goepferich, Achim (2015) Nanoparticles for the treatment of ocular neovascularizations. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 95. pp. 294-306. ISSN 0939-6411, 1873-3441
Full text not available from this repository. (Request a copy)Abstract
Neovascular diseases of the posterior eye like age-related macular degeneration, proliferative diabetic retinopathy or retinopathy of prematurity carry a tremendous burden for patient and health care system alike. Although intravitreal injections of anti-VEGF based therapeutics have significantly improved the visual outcome for many patients, current therapeutic options still show significant drawbacks such as the injection-related risk of contracting an infection. Due to their ability to encapsulate drugs with otherwise poor bioavailability, accumulate in areas of increased vascular permeability and control the release of active ingredients over time, nanoparticle systems have been widely researched to enhance current therapeutic strategies and expand the therapeutic arsenal. In this review, emphasis is placed both on the possibilities and drawbacks that a systemic nanoparticle-based therapy could have in the context of neovascular posterior eye diseases. Recent investigations into intravenous and intravitreal administration of nanomaterials and their potential to deliver potent drugs and genes to pathologic lesions will also be presented. Furthermore, we will focus on the exceptional anti-oxidative and anti-angiogenic properties of selected nanoscale systems that carve out new paths for the treatment of these severe posterior eye diseases. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL GROWTH-FACTOR; PIGMENT EPITHELIAL-CELLS; HUMAN BRUCHS MEMBRANE; INDUCED RETINAL NEOVASCULARIZATION; CERIUM OXIDE NANOPARTICLES; MACULAR DEGENERATION AMD; TARGETED DRUG-DELIVERY; INDUCED RAT MODEL; LASER-INDUCED CNV; CHOROIDAL NEOVASCULARIZATION; Nanoparticles; Age-related macular degeneration; Proliferative diabetic retinopathy; Retinopathy of prematurity; Drug delivery; Gene delivery; EPR effect; RGD peptide |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jun 2019 12:58 |
| Last Modified: | 07 Jun 2019 12:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4870 |
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