Marienhagen, Joerg and Weingartner, U. and Zerr, I. and Poser, S. and Blaha, L. and Eilles, C. (1999) Tc-99m-bicisate (ECD)-brain-SPECT in rapidly progressive dementia. NUKLEARMEDIZIN, 38 (6). pp. 203-206. ISSN 0029-5566,
Full text not available from this repository.Abstract
We present a 61-year-old male patient with progressive dementia. A brain SPECT with Tc-99m-bicisate was performed for confirmation of clinically suspected Alzheimer-dementia. At the lime of the SPECT-investigation marked apraxia and aphasia besides severe dementia were present. Electrophysiological as well as anatomical neuroimaging findings showed non-diagnostic alterations. SPECT revealed distinct perfusion defects, which made Alzheimer Dementia unlikely. The further course of the patient was determined by rapidly progressive deterioration with development of akinetic mutism. Thereafter increased levels of neuron-specific enolase as well as 14-3-3 proteins were found in the cerebro-spinal fluid (CSF). The patient finally died with signs of cerebral decortication. Due to the clinical course and the CSF-findings the patient's final diagnosis was Creutzfeldt-Jakob-disease, nevertheless no autopsy was performed. The presented case report underscores the clinical utility of perfusion brain SPECT in the differential diagnosis of dementias.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CREUTZFELDT-JAKOB-DISEASE; CEREBROSPINAL-FLUID; SPONGIFORM ENCEPHALOPATHIES; DIAGNOSIS; dementia; brain-SPECT; Creutzfeldt-Jakob-disease; Tc-99m-bicisafe; neuron-specific enolase; 14-3-3 Protein |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Dec 2022 07:35 |
| Last Modified: | 05 Dec 2022 07:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48709 |
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